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Perceptions of Adverse Childhood Experiences Among Lesbian, Gay, Bisexual, Tran...
Neves, Sofia; Ferreira, Mafalda; Sousa, Edgar; Topa, Joana; Borges, Janete; Vieira, Cristina P.Research shows lesbian, gay, bisexual, trans and intersex (LGBTI) people are vulnerable to more adverse childhood experiences (ACEs). The research focused on the perceptions of experiencing ACEs among 36 Portuguese LGBTI people who were exposed to domestic violence by their parents or other family members (M = 34.11; SD = 10.77). Semi-structured individual interviews were conducted and data were subjected to th...
Untangling sex differences in glia-to-neuron communication in chronic alcohol e...
Pacheco, Raquel; Canedo, Teresa; Rodrigues, Ana Margarida; Moreira, Joana; Relvas, João B.; Vieira, Cristina P.; Socodato, Renato; Sumavielle, TeresaExcessive alcohol consumption is global health challenge with profound neurobiological consequences. Our laboratory has shown that alcohol exposure induces reactive astrocytic changes, affecting gene expression, activity, and proliferation, while also altering microglial morphology and immune responses [1]. This study aims to characterise sex-specific effects of chronic alcohol consumption on the prefrontal cor...
In-silico prediction of the complete ataxin-3 protein network relevant for Spin...
Batista, Paulo; Vieira, Jorge; Vieira, Cristina P.; Faria, Brígida Mónica; Faria, Brigida MonicaSpinocerebellar ataxia type 3, also known as Machado Joseph disease (SCA3/MJD), is the most common inherited ataxia worldwide and is caused by a pathogenic expansion of the polyglutamine (polyQ) tract, located at the C-terminal region of the ataxin-3 protein (1). The polyQ region is involved in the stabilization of protein- protein interactions (PPIs). Abnormal polyQ expansion results in structural changes of t...
A new cyanobacterial species with a protective effect on lettuce grown under sa...
Brito, Ângela; Rocha, Mariana; Kaštovský, Jan; Vieira, Jorge; Vieira, Cristina P.; Ramos, Vitor; Correia, Manuel; Santos, Marina; Mota, RitaIn this work, a new terrestrial cyanobacterial species, Oculatella lusitanica LEGE 161147, was isolated and characterized using a polyphasic approach. Morphologically, O. lusitanica shares characteristics with different Oculatella species (mainly with O. crustae-formantes), lacking distinctive features. However, the phylogeny based on the 16S rRNA gene sequence and the 16S-23S ITS secondary structures support t...
Rewired glycosylation activity promotes scarless regeneration and functional re...
Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; Monteiro, Ana C.Regeneration of adult mammalian central nervous system (CNS) axons is abortive, resulting in inability to recover function after CNS lesion, including spinal cord injury (SCI). Here, we show that the spiny mouse (Acomys) is an exception to other mammals, being capable of spontaneous and fast restoration of function after severe SCI, re-establishing hind limb coordination. Remarkably, Acomys assembles a scarless...