9 documents found, page 1 of 1
BIONANOSCULP, an ongoing project in biotechnology applications for preventive c...
Moreira, P R; Silva, N; Pullar, R. C.; Ben-Arfa, B. A. E.; Abreu, J. G.; Henriques, F.; Pintado, M M E; Vieira, EThe objective of this paper is the presentation of the research strategies adopted and results of the ongoing BIONANOSCULP research project that is aiming to develop solutions in the area of sustainable nanomaterials, which are non-invasive and high-performance in their preventive conservation approach. An integrated methodology was designed as a holistic strategy to the characterisation of the microbiota prese...
LAMA2 gene mutation update: Toward a more comprehensive picture of the laminin-...
Oliveira, J; Gruber, A; Cardoso, M; Taipa, R; Fineza, I; Gonçalves, A; Laner, A; Winder, TL; Schroeder, J; Rath, J; Oliveira, ME; Vieira, E; Sousa, APCongenital muscular dystrophy type 1A (MDC1A) is one of the main subtypes of early-onset muscle disease, caused by disease-associated variants in the laminin-α2 (LAMA2) gene. MDC1A usually presents as a severe neonatal hypotonia and failure to thrive. Muscle weakness compromises normal motor development, leading to the inability to sit unsupported or to walk independently. The phenotype associated with LAMA2 de...
Oxidized low-density lipoprotein and lipoprotein(a) levels in chronic kidney di...
Ribeiro, S; Faria, MDS; Silva, G; Nascimento, H; Rocha-Pereira, P; Miranda, V; Vieira, E; Santos, R; Mendonça, D; Quintanilha, A; Costa, E; Belo, LChronic kidney disease (CKD) has been associated with an abnormal lipid profile. Our aim was to study the interplay between oxidized low-density lipoprotein (ox-LDL), adiponectin, and blood lipids and lipoproteins in Portuguese patients with CKD under hemodialysis (HD); the influence of the pentanucleotide repeat polymorphism in the apolipoprotein(a) (apo [a]) gene upon lipoprotein(a) (Lp[a]) levels in these pa...
LAMA2 Gene Analysis in a Cohort of 26 Congenital Muscular Dystrophy Patients
Oliveira, J; Santos, R; Soares-Silva, I; Jorge, P; Vieira, E; Oliveira, ME; Moreira, A; Coelho, T; Ferreira, JC; Fonseca, MJ; Barbosa, C; Prats, JCongenital muscular dystrophy type 1A (MDC1A) is caused by mutations in the LAMA2 gene encoding laminin-alpha2. We describe the molecular study of 26 patients with clinical presentation, magnetic resonance imaging and/or laminin-alpha2 expression in muscle, compatible with MDC1A. The combination of full genomic sequencing and complementary DNA analysis led to the particularly high mutation detection rate of 96%...
Acute lymphoblastic leukemia in childhood. A 10-year experience with the DFCI 8...
de Lacerda, A F; Chagas, M; Neto, A; Vieira, E; Ribeiro, M J; Pereira, F; Ambrósio, A; Sousinha, MAcute lymphoblastic leukemia is the most frequently encountered pediatric cancer. Approximately 70% of cases can be cured of the disease. In this article, we describe the experience of our Center in the last ten years with a treatment protocol adapted from protocol DFCI 81-01 (from the Dana Farber Cancer Institute, Boston). We conclude that it is easily accomplished, well tolerated and that it allowed us to sig...
Monoclonal antibodies. General approach and radioimmunotherapy.
Sousa, O; Vieira, ETwo major obstacles to systemic cancer therapy are the lack of specificity of therapeutic modalities and the intrapatient and interpatient heterogeneity of cancer cells. Because of their natural specificity, antibodies directed against tumor specific or tumor associated antigens have been raising interest in oncology. This article makes an overview of the basic principles of monoclonal antibodies, their limitat...
Gliosarcomas.
Sousa, O; Honavar, M; Fernandes, T; Vieira, E; Lopes, CGliosarcomas are rare tumors of the central nervous system with a poor prognosis. Histologically these tumors are characterized by an admixture of neoplastic glial cells and sarcomatous elements. Due to the scarcity of data in literature, the diagnosis is often missed and treatment is difficult. The authors report three cases of cerebral gliosarcomas and review the literature on this subject.; Gliosarcomas are ...
The role of external radiotherapy in the treatment of medullary carcinoma of th...
Costa, M A; Sousa, O; Azevedo, I; Castro, C; Fernandes, T; Vieira, EMedullary carcinoma of the thyroid represents 3 to 10% of all thyroid cancers. Surgery is the main treatment. External beam radiotherapy has a fundamental role in the treatment of residual disease following surgery, in cases of cervical node involvement, and in unresectable tumors. Between 1975 and 1993, 12 patients with medullary carcinoma of the thyroid were treated at the Department of Radiotherapy of the Po...
Primary lymphomas of the brain not related to immunodeficiency.
Marques, H; Ferreira, E; Oliveira, A; Proença, G; Marques, M; Teixeira, P; Vieira, E; Viseu, FPrimary brain lymphoma (PBL) is a rare disease, the study of which is based on small series and case reports. The AA review new cases of PBL not associated to immunodeficiency at the Portuguese Institute of Oncology of Porto since 1978. Five male patients were found with lymphoma primarily located in the brain, with aggressive histology, IE staging, detected by CAT, NMR or brain scintigraphy and with histologic...