2 documents found, page 1 of 1
Role of rutin in 5-Fluorouracil-induced intestinal mucositis : prevention of hi...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Martins, Conceição da Silva; Barbosa, Maria Lucianny Lima; Pimenta, Helder BindáIntestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana, exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory process...
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diéster...
Canabrava, Natália do Vale; Silva, Jose Ytalo Gomes da; Silva, Bruno Bezerra da; Holanda, Marcelo Oliveira; Lima, Carla Laine SilvaP-methoxycinnamic diesters from carnauba wax powder (PCO - C) – cinnamic acid derivate – have been associated with new properties such as hypolipidemic, hypocholesterolemic and hypoglycaemic effects in mice. The present study aimed to investigate the safety profile of PCO - C by evaluating the subchronic oral toxicity, genotoxicity and mutagenicity using in vivo experimental models. Therefore, for the present r...