193 documents found, page 1 of 20

Screening and in silico characterization of prophages in Helicobacter pylori cl...

The increase of antibiotic resistance calls for alternatives to control Helicobacter pylori, a Gram-negative bacterium associated with various gastric diseases. Bacteriophages (phages) can be highly effective in the treatment of pathogenic bacteria. Here, we developed a method to identify prophages in H. pylori genomes aiming at their future use in therapy. A polymerase chain reaction (PCR)-based technique test...

Genetic variants in the IFNGR2 locus associated with severe chronic Q fever

Q fever is a highly contagious zoonosis capable of causing large outbreaks of important health and economic consequences. Host genetic factors are believed to influence the development of severe chronic Q fever following the infection by the etiological agent, Coxiella burnetii. Targetted next generation sequencing (NGS) was performed in a case-control genetic association study on 53 confirmed Q fever cases, in...

Análise genómica no Serviço Nacional de Saúde: modelo colaborativo INSA–ULSSM p...

Compartment Syndrome Following Extravasation of Contrast: A Case Report.

Acute compartment syndrome is a rare but serious complication of intravenous contrast extravasation, which can cause tissue ischemia and necrosis if not recognized and treated promptly. We report the case of a 56-year-old female with a history of breast cancer who developed acute compartment syndrome of the right hand and forearm after extravasation of approximately 20-30 mL of iodinated contrast agent administ...

Transcriptomic response of Mytilus galloprovincialis to emerging contaminants: ...

Introduction: Environmental pollutants such as tetrabromobisphenol A (TBBPA), perfluoroalkyl substances (PFASs) like perfluorooctanoic acid (PFOA), and endocrine-disrupting compounds (EDCs) as 17α-ethinylestradiol (EE2) are commonly detected in coastal ecosystems. The Mediterranean mussel, Mytilus galloprovincialis, is a species of significant ecological and economic importance. Recent genomic studies have reve...

Genome-wide methylation changes upon Caco-2 cells exposure to undigested and di...

Introduction: Titanium dioxide nanoparticles (TiO2NPs) are relevant nanomaterials (NMs) for biomedicine and industry, which raise concerns about its effects on human health, particularly through ingestion. Several studies found that exposure to NMs can lead to DNA methylation changes. DNA methylation regulates gene expression, playing a vital role in development and disease, with aberrant methylation linked to ...

Engagement dos docentes no trabalho: um olhar às implicações da pandemia

Educação inclusiva em contexto de pandemia: implicações e desafios

Ingested titanium dioxide nanomaterials: new approach to investigate intestinal...

Oral exposure to titanium dioxide nanomaterials (TiO2NMs) is due to their presence in food, food contact materials, medicines and cosmetics. The gastrointestinal tract(GIT) represents primary site of contact, that may result in systemic exposure, if biological barriers are surpassed. The INGESTnano project aimed to investigate nano-bio interactions at the cellular/molecular levels within the context of the inte...

Comparative analysis of hybrid‑SNP microarray and nanopore sequencing for detec...

Background: Nanopore sequencing is a technology that holds great promise for identifying all types of human genome variations, particularly structural variations. In this work, we used nanopore sequencing technology to sequence 2 human cell lines at low depth of coverage to call copy number variations (CNV), and compared the results variant by variant with chromosomal microarray (CMA) results. Results: We analy...