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Preclinical assessment of an antibiotic-free cationic surfactant-based cellulos...
Calado, Rita D.A.; Mendes, Bárbara B.; Conniot, João; Ravasco, João M.J.M.; Sobral, Daniel; Ferreira, Carolina; Ferreira, Rita; Rodrigues, João CarlosSexually transmitted infections and urogenital-perinatal infections are significant health challenges owing to their asymptomatic nature, multidrug-resistant pathogens, and lack of effective vaccines. Surfactants are under investigation as potential antimicrobial agents and alternatives to traditional antibiotics. Here, we discovered that N-dodecylpyridinium bromide (C12PB), a cationic quaternary ammonium surfa...
Rab8 is required for phagocytosis and phagosomal maturation
Jordão, Luísa; Ramalho, Jose; Seabra, Miguel; Vieira, Otilia V.
Tuberculosis: new aspects of an old disease
Jordão, Luísa; Vieira, Otilia V.Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculo...
Rab10 regulates phagosome maturation and its overexpression rescues Mycobacteri...
Cardoso, Carla M. P.; Jordão, Luísa; Vieira, Otilia V.Phagosome maturation follows a defined biochemical program and, in the vast majority of cases, the microbe inside the phagosome is killed and digested. Although, an important number of pathogens, including Mycobacterium tuberculosis, which kills around two million people every year, have acquired the ability to survive, and even replicate by arresting phagosomal maturation. To identify more of the machinery inv...