8 documents found, page 1 of 1
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, I; Macedo, D; Gouveia, E; Ferreira, A; Lima, J; Lopez, D; Melo-Alvim, C; Carvalho, A; Tavares, P; Rodrigues-Santos, P; Cardoso, PSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outc...
Temmink, SJ; Peeters, KC; Bahadoer, R; Kranenbarg, MK; Roodvoets, AG; Melenhorst, J; Burger, JW; Wolthuis, A; Renehan, AG; Figueiredo, NL; Pares, OrBackground: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wa...
Measuring Adherence to Inhaled Control Medication in Patients with Asthma: Comp...
Cachim, A; Pereira, AM; Almeida, R; Amaral, R; Alves‐Correia, M; Vieira‐Marques, P; Chaves‐Loureiro, C; Ribeiro, C; Cardia, F; Gomes, J; Vidal, CBackground: Previous studies have demonstrated the feasibility of using an asthma app to support medication management and adherence but failed to compare with other measures currently used in clinical practice. However, in a clinical setting, any additional adherence measurement must be evaluated in the context of both the patient and physician perspectives so that it can also help improve the process of share...
Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis
Cardoso, A; Martins, AC; Maceiras, AR; Liu, W; Castro, I; Castro, AG; Bandeira, A; Di Santo, JP; Cumano, A; Li, Y; Vieira, P; Saraiva, MIn emergency myelopoiesis (EM), expansion of the myeloid progenitor compartment and increased myeloid cell production are observed and often mediated by the pro-inflammatory cytokine interferon gamma (IFN-γ). Interleukin-10 (IL-10) inhibits IFN-γ secretion, but paradoxically, its therapeutic administration to humans causes hematologic changes similar to those observed in EM. In this work, we use different in vi...
Crescent-like lesions as an early signature of nephropathy in a rat model of pr...
Nunes, S; Alves, A; Preguiça, I; Barbosa, A; Vieira, P; Mendes, F; Martins, D; Viana, SD; Reis, FDiabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly ...
The Dynamics of Interleukin-10-afforded protection during dextran sulfate sodiu...
Cardoso, A; Castro, A; Martins, AC; Carriche, GM; Murigneux, V; Castro, I; Cumano, A; Vieira, P; Saraiva, MInflammatory bowel disease encompasses a group of chronic-inflammatory conditions of the colon and small intestine. These conditions are characterized by exacerbated inflammation of the organ that greatly affects the quality of life of patients. Molecular mechanisms counteracting this hyperinflammatory status of the gut offer strategies for therapeutic intervention. Among these regulatory molecules is the anti-...
Metabolic Profile and Cardiovascular Risk in a Population of Renal transplant r...
Gonçalves, M; Vieira, P; Resende, L; Durães, J; Rosa, N; Teixeira, JA; Silva, GIntroduction. Cardiovascular disease is more common in renal transplant recipients (RTRs) than in the general population, and is the major cause of both graft loss and patient death in RTRs. Objectives. This study aimed to characterize the cardiovascular risk factors, calculate the 7-year risk for major adverse cardiac events and the 7-year risk for death in a population of RTRs using a cardiovascular risk calc...
Renal Disease in Madeira Islands: Twenty-Seven Years' Experience of Native Kidn...
Vieira, P; Gonçalves, AM; Durães, JM; Rosa, N; Resende, L; Silva, G; Alves Teixeira; Rodrigues, F; Galvão, MJ; Brinca, A; Viana, H; Carvalho, FIntroduction: Renal biopsy plays an essential role either in the diagnosis or in the prognosis of patients with renal disease. In order to assess its epidemiology and evolution in Madeira Islands, we analysed twenty-seven years of native kidney biopsies. Methods: We performed a retrospective analysis of clinical records, including histological revision from 1986 to 2012, totalling 315 native kidney biopsies. Th...