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Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhan...

Léveillé, Nicolas; Melo, Carlos A.; Rooijers, Koos; Díaz-Lagares, Angel; Melo, Sonia A.; Korkmaz, Gozde; Lopes, Rui; Moqadam, Farhad Akbari; Maia, Ana R

p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-binding sites, most did not. As long non-coding RNAs (lncRNAs) are prominent regulators of chromatin dynamics, we hypothesized that p53-induced lncRNAs contribute to the activation of enhancers by p53. Among ...

Date: 2015   |   Origin: Estudo Geral - Universidade de Coimbra
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