2 documents found, page 1 of 1
The Retropepsin-Type Protease APRc as a Novel Ig-Binding Protein and Moonlighti...
Curto, Pedro; Barro, Andreia; Almeida, Carla; Vieira-Pires, Ricardo S.; Simões, IsauraRickettsiae are obligate intracellular Gram-negative bacteria transmitted by arthropod vectors. Despite their reduced genomes, the function(s) of the majority of rickettsial proteins remains to be uncovered. APRc is a highly conserved retropepsin-type protease, suggested to act as a modulator of other rickettsial surface proteins with a role in adhesion/invasion. However, APRc's function(s) in bacterial pathoge...
Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the Kt...
Szollosi, Andras; Vieira-Pires, Ricardo S.; Teixeira-Duarte, Celso M.; Rocha, Rita; Morais-Cabral, João H.KtrAB belongs to the Trk/Ktr/HKT superfamily of monovalent cation (K+ and Na+) transport proteins that closely resemble K+ channels. These proteins underlie a plethora of cellular functions that are crucial for environmental adaptation in plants, fungi, archaea, and bacteria. The activation mechanism of the Trk/Ktr/HKT proteins remains unknown. It has been shown that ATP stimulates the activity of KtrAB while A...