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Acrocomia aculeata associated with doxorubicin: cardioprotection and anticancer...
Monteiro-Alfredo, Tamaeh; Dos Santos, Jéssica Maurino; Antunes, Kátia Ávila; Cunha, Janielle; da Silva Baldivia, Debora; Pires, Ana SaloméDoxorubicin (Dox) is a chemotherapeutic agent widely used in the clinic, whose side effects include cardiotoxicity, associated with decreased antioxidant defenses and increased oxidative stress. The association of Dox with natural antioxidants can extend its use if not interfering with its pharmacological potential. In this study, we aimed to understand the effects and mechanisms of the aqueous extract of Acroc...
Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives
Pires, Ana Salomé; Bollini, Sveva; Botelho, Maria Filomena; Lang-Olip, Ingrid; Ponsaerts, Peter; Balbi, Carolina; Lange-Consiglio, AnnaThe last 18 years have brought an increasing interest in the therapeutic use of perinatal derivatives (PnD). Preclinical studies used to assess the potential of PnD therapy include a broad range of study designs. The COST SPRINT Action (CA17116) aims to provide systematic and comprehensive reviews of preclinical studies for the understanding of the therapeutic potential and mechanisms of PnD in diseases and inj...
The Potential Effect of Lidocaine, Ropivacaine, Levobupivacaine and Morphine on...
Matos, Ana Catarina; Marques, Inês Alexandra; Pires, Ana Salomé; Valentim, Ana; Abrantes, Ana Margarida; Botelho, Maria FilomenaBreast cancer (BC) is one of the most common types of cancer and the second leading cause of death in women. Local anaesthetics (LAs) and opioids have been shown to influence cancer progression and metastasis formation in several pre-clinical studies. However, their effects do not seem to promote consensus. A systematic review was conducted using the databases Medline (via PubMed), Scopus, and Web of Science (2...
Study Protocol of a Multicenter Randomized Controlled Trial to Tackle Obesity t...
Boqué, Noemi; Tarro, Lucía; Rosi, Alice; Torrell, Helena; Saldaña, Guillermo; Luengo, Elisa; Rachman, Zeev; Pires, António; Tavares, Nuno TiagoYouth obesity is a strong predictor of adult obesity, which has well-known negative health consequences. Thus, addressing adult obesity requires tackling youth obesity. MED4Youth's main objective is to strengthen the link between the Mediterranean Diet (MD) and the health benefits against youth obesity and associated cardiovascular disease (CVD) risk factors, identifying positive effects exerted by an MD includ...
Synthesis, Characterization and Evaluation of the Antibacterial and Antitumor A...
Pires, Ana Salomé; Batista, João; Murtinho, Dina; Nogueira, Célia; Karamysheva, Anna; Ramos, Maria Luísa; Milne, Bruce; Tavares, Nuno TiagoPlatinum metal complexes are the most common chemotherapeutics currently used in cancer treatment. However, the frequent adverse effects, as well as acquired resistance by tumor cells, urge the development of effective alternatives. In the recent past, copper complexes with Schiff base ligands have emerged as good alternatives, showing interesting results. Accordingly, and in continuation of previous studies in...
Cytogenetic alterations induced by radiation in amniocytes
Pires, Ana Salomé; Pinto, Marta; Silveira, Paula; Brito, Ana Filipa; Fonseca, Sérgio; Castro, Ismael; Dias, Sílvia; Cunha, Ana Luísa; Ferreira, MarisaWhen cells are submitted to ionizing radiation, they respond with physico-chemical phenomena like ionization/excitation of atoms and energy distribution over the cells, chemical reactions with formation of free radicals and rupture of chemical bonds and biological alterations leading to specific changes of cellular functions with decrease of cellular activity. Therefore, both tissues and organs are affecte...