2 documents found, page 1 of 1
Mycobacterium tuberculosis infection up-regulates sialyl lewis x expression in ...
Matos, R; Fonseca, KL; Mereiter, S; Maceiras, AR; Gomes, J; Vilaplana, C; Gärtner, F; Rodrigues, P; Reis, CA; Saraiva, M; Magalhães, AGlycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown. This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis. We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway in...
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neu...
Moreira-Teixeira, L; Stimpson, PJ; Stavropoulos, E; Hadebe, S; Chakravarty, P; Ioannou, M; Aramburu, IV; Herbert, E; Priestnall, SL; Suarez-Bonnet, ATuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB. Here we show that similar transcriptional signatures correlate with increased bacterial loads and exacerbate pat...