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Salivary biomarkers in psychological stress diagnosis
Batista, Patrícia; Pereira, Anabela; Vaz, Ana BeatrizBackground: Nowadays, the search for biomarkers has attracted attention in medical and psychological sciences. The biomarkers are crucial to prevent diseases, to detect pathologies and to induce quality of life in patients. Recent studies evaluate stress biomarkers and provide information about physiological and psychological organism reactions to stressors. These biomarkers can be assessed via motoring corpora...
Decavanadate contribution to vanadium biomarkers
Aureliano, M.The levels of vanadium in urine and blood can be used as biomarkers of exposure, but the mechanism of vanadium toxicity is of major relevance in order to understand how biomarkes can be valuable. Our research group has performed in vivo and in vitro studies using fish and rat models to analysed and compare the toxicity effects induce by vanadium(V) species in the forms of vanadate (V1) and decavanadate (V10). V...
Infection biomarkers based on metabolomics
Araújo, Rúben; Bento, Luís; Fonseca, Tiago AH; Von Rekowski, Cristiana; Ribeiro Da Cunha, Bernardo; Calado, CecíliaCurrent infection biomarkers are highly limited since they have low capability to predict infection in the presence of confounding processes such as in non-infectious inflammatory processes, low capability to predict disease outcomes and have limited applications to guide and evaluate therapeutic regimes. Therefore, it is critical to discover and develop new and effective clinical infection biomarkers, especial...
Biomarkers for seasonal heat stress
Pinheiro, C.; Lamy, E.; Pereira, A.M.F.Environmental heat stress, present during the hot and dry summers in Mediterranean climate, severely impairs animal’s performance, particularly in animals of high genetic merit. Although heat stress has been considerable studied in dairy cattle, the mechanisms of seasonal acclimation are less well understood. Biomarkers may have great potential in identifying levels of thermal stress. The blood cortisol does no...
The relevance of effect biomarkers in human biomonitoring
Gomes, Bruno; Louro, Henriqueta; Silva, Maria JoãoA fundamental goal of environmental/occupational health policy is to reduce and, whenever possible, prevent human exposure to chemical substances that may lead to morbidity or mortality. Human biomonitoring (HBM) allows the assessment of the levels of certain substances in the body, through the analysis of biomarkers of exposure (chemical substances, metabolites) and it has been considered as an extremely impor...
Biomarkers in neurodegenerative diseases: cortisol
Batista, Patrícia; Pereira, AnabelaNeurodegenerative diseases are characterized by progressive loss of cognitive function, dementia, and problems with movements. Identification of biomarkers during disease process, induce to an effective and early diagnostic test for neurodegenerative diseases. These biomarkers would allow presymptomatic disease detection of disease and would be valuable for monitoring the efficacy of disease. Cortisol is a biom...
Biomarkers for Alzheimer's disease therapeutic trials
Hampel, Harald; Wilcock, Gordon; Andrieu, Sandrine; Aisen, Paul; Blennow, Kaj; Broich, K.; Carrillo, Maria; Nick, C. Fox; Frisoni, Giovanni B.The development of disease-modifying treatments for Alzheimer's disease requires innovative trials with large numbers of subjects and long observation periods. The use of blood, cerebrospinal fluid or neuroimaging biomarkers is critical for the demonstration of disease-modifying therapy effects on the brain. Suitable biomarkers are those which reflect the progression of AD related molecular mechanisms and neuro...
Biomarkers of fitness and welfare in dairy cattle: healthy productivity
Zachut, M.; Speranda, M.; Almeida, A.M.; Gabai, G.; Mobasheri, A.; Hernandez-Castellano, L.Milk production intensification has led to several unwanted aspects, such as sustainability issues and environmental pollution. Among these, increased milk outputs that have been achieved over the last 70 years have led to several health and pathophysiological conditions in high yielding dairy animals, including metabolic diseases that were uncommon in the past. Increased occurrence of diverse metabolic disease...
Exploring salivary biomarkers in pediatric obesity: a scoping review
Sabella, Fernanda Maria; Katzenelson, Renata Thomaz; Carvalho, Fabíola Galbiatti de; Duque, Cristiane; Darrieux, Michelle; Marson, Fernando Augusto LimaChildhood obesity and overweight are linked to subclinical inflammatory conditions. The present manuscript aimed to undertake a scoping review exploring the relationship between childhood obesity and salivary biomarkers to answer the following question: “Are salivary biomarkers trustful factors/indicators for childhood obesity?” The main search terms used were: “obesity and salivary biomarkers and children” (Pu...
Inflammatory Biomarkers in Diabetic Macular Edema
Campos, António; Furtado, Maria João; Carneiro, Ângela; Meireles, Angelina; Neves, Carlos; Ambrósio, António Francisco; Leal, Inês; Figueira, JoãoDiabetic retinopathy (DR) is a major complication of both Type 1 and Type 2 diabetes mellitus (T1DM and T2DM). Disease progression can result in visual impairment, primarily due to diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR). Although several ocular treatments are available for DME, a subset of patients fails to respond, reflecting the multifactorial, complex, and systemic nature of...