4 documents found, page 1 of 1
Machine Learning-based Prediction Model for Treatment of Acromegaly with First-...
Wildemberg, Luiz Eduardo; Da Silva Camacho, Aline Helen; Miranda, Renan Lyra; Elias, Paula C. L; De Castro Musolino, Nina R; Nazato, DeboraMade available in DSpace on 2022-04-29T08:29:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01; Context: Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response to first-generation somatostatin receptor ligands (fg-SRLs) in the treatment of acromegaly. Objective: To develop a prediction model of therapeutic response of acromegaly to f...
Brazilian multicenter study on pegvisomant treatment in acromegaly
Boguszewski, Cesar L.; Huayllas, Martha Katherine P; Vilar, Lucio; Naves, Luciana Ansaneli; Ribeiro-Oliveira Junior, Antonio; Soares, Beatriz SantanaObjective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during trea...
Controversial issues in the management of hyperprolactinemia and prolactinomas ...
Vilar, Lucio; Abucham, Julio; Albuquerque, José Luciano; Araujo, Luiz Antônio; Azevedo, Monalisa F.; Boguszewski, Cesar Luiz; Casulari, Luiz AugustoProlactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction,...
A review of Cushing's disease treatment by the Department of Neuroendocrinology...
Machado, Márcio Carlos; Fragoso, Maria Candida Barisson Vilares; Moreira, Ayrton Custódio; Boguszewski, César Luiz; Vieira Neto, LeonardoThe treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority...