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Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Ce...
Benvenutti,Régis Carlos; Gomes,Denise B.; Zanchet,Barbara; Locateli,Gelvani; Vechia,Cristian Alex Dalla; Zanotelli Serpa,Patrícia; Lutinski,JunirAbstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. How...
Operculina macrocarpa: chemical and intestinal motility effect in mice
Paganotte,Daniele Michelin; Sannomiya,Miriam; Rinaldo,Daniel; Vilegas,Wagner; Salgado,Hérida R.N.ABSTRACT Operculina macrocarpa (L.) Urb., Convolvulaceae, is used by the population as a laxative. In this work we described the isolation of the three phenolic acids present in the hydroethanolic extract of the O. macrocarpa roots. The quantification of the caffeic, chlorogenic acids and of the new caffeic dimer in the hydroethanolic and infusion extracts was performed by high-performance liquid chromatography...
Evaluation of mutagenicity and metabolism-mediated cytotoxicity of the naphthoq...
Kitagawa,Rodrigo R.; Vilegas,Wagner; Varanda,Eliana A.; Raddi,Maria S.G.A large number of quinones have been associated with antitumor, antibacterial, antimalarial, and antifungal activities. Results of previous studies of 5-methoxy-3,4-dehydroxanthomegnin, a naphthoquinone isolated fromPaepalanthus latipes Silveira, Eriocaulaceae, revealed antitumor, antibacterial, immunomodulatory, and antioxidant activities. In this study, we assessed the mutagenicity and metabolism-mediated cyt...
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabida...
Rocha,Cláudia Q. da; Vilela,Fabiana C.; Santa-Cecília,Flávia V.; Cavalcante,Gustavo P.; Vilegas,Wagner; Giusti-Paiva,Alexandre; Santos,Marcelo H. dosAbstractArrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and ho...
HPLC-DAD based method for the quantification of flavonoids in the hydroethanoli...
Amorim,Marcelo R. de; Rinaldo,Daniel; Amaral,Fabiano P. do; Vilegas,Wagner; Magenta,Mara A. G.; Vieira Jr,Gerardo M.; Santos,Lourdes C. dosThis article describes the isolation and identification of flavonoids in the hydroethanolic extract of the aerial parts from Tonina fluviatilis and evaluation of their antiradical activity. A method based on HPLC-DAD was developed and validated for detecting and quantifying flavonoids in hydroethanolic extracts. The flavonoids identified and quantified in the extract were 6,7-dimethoxyquercetin-3-O-β-D-glucopyr...
Paepalanthus spp: antimycobacterial activity of extracts, methoxylated flavonoi...
Moreira,Raquel R. D.; Martins,Gilmarcio Z.; Pietro,Rosemeire C. L. R.; Sato,Daisy N.; Pavan,Fernando R.; Leite,Sergio R.A.; Vilegas,WagnerPaepalanthus spp., Eriocaulaceae, are native plants from Brazil known as "sempre-vivas" (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-β-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The ...
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphtho...
Kitagawa,Rodrigo Rezende; Bonacorsi,Cibele; Fonseca,Luiz Marcos da; Vilegas,Wagner; Raddi,Maria Stella GonçalvesHelicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host Keywords: immune cells (especially neutrophils) release inflammatory mediators and large 5-methoxy-3,4-dehydroxanthomegnin amounts of reactive oxygen species (ROS), which are associated wi...
Chronic administration of Abarema cochliacarpos attenuates colonic inflammation...
Silva,Maria Silene da; Sánchez-Fidalgo,Susana; Cárdeno,Ana; Talero,Elena; Silva,Marcelo Aparecido da; Vilegas,Wagner; Brito,Alba R. M. SouzaInflammatory bowel diseases are characterized by a chronic clinical course of relapse and remission associated with self-destructive inflammation of the gastrointestinal tract. Active extracts from plants have emerged as natural potential candidates for its treatment. Abarema cochliacarpos (Gomes) Barneby & Grimes, Fabaceae (Barbatimão), is a native medicinal plant in to Brazil. Previously we have demonstra...
Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehy...
Kitagawa,Rodrigo Rezende; Vilegas,Wagner; Carlos,Iracilda Zeppone; Raddi,Maria Stella GonçalvesLarge number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a sign...
Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone
Camargo,Mariana S.; Varela,Soraya D.; Oliveira,Ana Paula S. de; Resende,Flávia Ap.; Cuesta-Rubio,Osmay; Vilegas,Wagner; Varanda,Eliana A.Currently, a wide range of research involving natural products is focused on the discovery of new drugs in many different therapeutic areas. A great number of the synthetic compounds on the market were derived from natural products, especially plants. Nemorosone is the major constituent of the floral resin of Clusia rosea Jacq., Clusiaceae, and in Cuban propolis. In vitro studies have shown cytotoxic activity i...