7 documents found, page 1 of 1
Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis
Vilela, Márcia Carvalho; Lima, Graciela Kunrath; Rodrigues, David Henrique; Lacerda-Queiroz, Norinne; Pedroso, Vinicius Sousa PietraThe neuroinflammatory response aimed at clearance of herpes simplex virus-1 (HSV-1) plays a key role in the pathogenesis of neuroaxonal damage in herpetic encephalitis. Leukocytes activated in an adaptive immune response access brain tissue by passing through the blood–brain barrier. The chemokine CCL5/RANTES is involved in recruitment of these cells to the brain acting via the receptors CCR1, CCR3 and mainly C...
Imipramine reverses depressive-like parameters in pneumococcal meningitis survi...
Vilela, Márcia Carvalho; Barichello, Tatiana; Milioli, Graziele; Generoso, Jaqueline S.; Cipriano, Andreza L.; Costa, Caroline S.; Moreira, Ana PaulaPneumococcal meningitis is a severe infectious disease of the central nervous system, associated with acute inflammation and might cause damage to the host, such as deafness, blindness, seizure, and learning deficits. However, infectious diseases can play a significant role in the etiology of neuropsychiatric disturbances. In this context, we evaluated depressive-like parameters; corticosterone and ACTH levels ...
Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adu...
Vilela, Márcia Carvalho; Barichello, Tatiana; Generoso, Jaqueline S.; Simões, Lutiana R.; Elias, Samuel G.; Tashiro, Michael H.; Dominguini, DiogoStreptococcus pneumoniae is a common cause of forms of bacterial meningitis that have a high mortality rate and cause long-term neurologic sequelae. We evaluated the effects of an indoleamine 2,3-dioxygenase (IDO) inhibitor on proinflammatory mediators and memory in Wistar rats subjected to pneumococcal meningitis. The animals were divided into 4 groups: sham, sham treated with IDO inhibitor, meningitis, and me...
Cannabidiol reduces host immune response and prevents cognitive impairments in ...
Barichello, Tatiana; Ceretta, Renan A.; Generoso, Jaqueline S.; Moreira, Ana Paula; Simões, Lutiana R.; Comim, Clarissa M.; Quevedo, JoãoPneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended admi...
Neonatal Escherichia coli K1 meningitis causes learning and memory impairments ...
Vilela, Márcia Carvalho; Barichello, Tatiana; Dagostim, Valdemira S.; Generoso, Jaqueline S.; Simões, Lutiana R.; Dominguini, Diogo; Silvestre, CintiaNeonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood–brain barrier integrity in neonatal rats following E. coli K1 experimental meningitis infection and subsequent behavioural parameters in adulthood. In the hippocampus, in...
Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in n...
Teixeira, Antonio Lucio; Barichello, Tatiana; Lemos, Joelson C.; Generoso, Jaqueline S.; Cipriano, Andreza L.; Milioli, Graziele L.We verify the levels of cytokine/chemokine, myeloperoxidase activity, oxidative stress and disruption of BBB in hippocampus and cortex of the neonate Wistar rats after meningitis by S. agalactiae. In the hippocampus the levels were increased of CINC-1 at 6 h and 12 h, IL-1β at 6, 12 and 24 h, IL-6 at 6, 24 and 96 h, IL-10 at 24, 48 and 96 h and TNF-α at 24 h and 96 h. In the cortex the CINC-1 and IL-1β levels w...
Brain–blood barrier breakdown and pro-inflammatory mediators in neonate rats su...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Moreira, Ana Paula; Costa, Caroline S.; Zanatta, Jessiele R.; Simões, Lutiana R.Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured bra...