2 documents found, page 1 of 1
Successful vaccination against Leishmania chagasi infection in BALB/c mice with...
Vilela, Márcia de Carvalho; Gomes, Daniel Cláudio de Oliveira; Silva, Eduardo de Almeida Marques da; Serafim, Tiago DonatelliThis study evaluated the potential of a Leishmania antigen vaccine in protecting BALB/c mice against Leishmania chagasi. Mice received two subcutaneous doses of L. amazonensis vaccine with Corynebacterium parvum and subsequent boost was done without adjuvant. One week later, mice were challenged with L. chagasi. We observed that this vaccine caused a significant reduction in parasite load in liver and spleen an...
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo : an int...
Queiroz, Norinne Lacerda; Lima, Onésia Cristina Oliveira; Carneiro, Cláudia Martins; Vilela, Márcia de Carvalho; Teixeira, Antônio LúcioMalaria is second only to tuberculosis as the leading cause of morbidity and mortality as a consequence of a single infectious agent. Much of the pathology of malaria arises from the inappropriate or excessive immune response mounted by the host in an attempt to eliminate the parasite. We here report the inflammatory changes observed in the cerebral microvasculature of C57BL/6 and BALB/c mice that had been inoc...