Introduction: Squamous cell carcinoma (SCC) of the penis is a rare but devastating neoplasm for the patient. Human Papillomavirus (HPV) infection can induce penile carcinogenesis and may contribute to 30 to 50% of penile cancer (PeCa) cases. The overexpression of P16INK4a can be used as a surrogate marker for active HPV infections, although the correlation between HPV infection in PeCa still is controversial. K...