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Human Papilomavirus infection and Ki-67 expression in Penile Cancer: Do they re...

Mendes, Fernando; Vilela, Marisa; Silva, Edgar Tavares; Quaresma, Vasco; Almeida, Rui; Silva, Maria Fátima; Teixeira, Paulo; Martins, Diana

Introduction: Squamous cell carcinoma (SCC) of the penis is a rare but devastating neoplasm for the patient. Human Papillomavirus (HPV) infection can induce penile carcinogenesis and may contribute to 30 to 50% of penile cancer (PeCa) cases. The overexpression of P16INK4a can be used as a surrogate marker for active HPV infections, although the correlation between HPV infection in PeCa still is controversial. K...


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