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DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic...

This review examines the emerging roles of DICER1 and DGCR8, key components of the miRNA biogenesis pathway, in thyroid pathogenesis, with a particular focus on their association with oncocytic morphology. Recent findings have expanded our understanding of DICER1 syndrome and DGCR8-related thyroid disorders, revealing a broader spectrum of thyroid lesions associated with mutations in these genes than previously...

Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma

MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper ...

Aprendizagem com base em processos de cocriação: o exemplo do DEMOLA® no Instit...

Assistimos, atualmente a inúmeras parcerias e projetos de âmbito nacional e internacional na área da formação ativa, com recurso à utilização de ferramentas digitais e assentes em processos de cocriação entre diferentes parceiros, com o objetivo de se obterem processos/percursos mais criativos e adequados, que respondam de forma eficaz aos desafios científicos que vivemos e se avizinham. Neste artigo procede-se...

Co-creation design thinking process: learning with Demola approach

Generation of an obese diabetic mouse model upon conditional Atrx disruption

ATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homo...

DGCR8 microprocessor subunit mutation and expression deregulation in thyroid le...

Deregulation of microRNA (miRNA) processing is a driver event in several tumours including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex component, and in the development of the thyroid. Previous studies identified a DGCR8 mutation – the variant c.1552G>A p.(E518K) – in cases of thyroid cancer and proposed to cause a familial syndr...

Evaluation of RRAS2 and TTP1 promoter mutations in thyroid tumours

Thyroid cancer is the most frequent endocrine neoplasm, being the tenth most prevalent in both genders and it presenting an overall good prognosis [1]. Ras related 2 (R-Ras2), also known as TC21, is a GTP-binding protein that together with R-Ras1 and R-Ras3, is part of the R-Ras GTPase subfamily. Mutations in RRAS2 gene in the long-tailed hotspot Q72L/H block the hydrolysis of guanosine triphosphate (GTP) in Ra...

Student Participation: Issues for the Governance of Higher Education

The paper reports findings of a research project aimed at developing insight into student participation in the governance of higher education institutions. The project was carried out in two institutions in Portugal, analyzing numbers and forms of participation, identifying facilitators and constraints to participation, and analyzing the students’ perceptions of their own participation. The study was carried ou...

Hyperparameter self-tuning for data streams

The number of Internet of Things devices generating data streams is expected to grow exponentially with the support of emergent technologies such as 5G networks. Therefore, the online processing of these data streams requires the design and development of suitable machine learning algorithms, able to learn online, as data is generated. Like their batch-learning counterparts, stream-based learning algorithms req...

Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review

Bladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by in...