Purpose: To compare differences in the foveal avascular zone (FAZ) area, measured in the Superficial Vascular Complex (SVC), Deep Vascular Complex (DVC), and a combined analysis of both (SDVC), using two Spectral Domain OCT angiography (OCT-A) protocols, High Speed (HS) and High Resolution (HR). Methods: A total of 26 eyes of diabetic patients, with and without macular oedema, were examined with two different f...
Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...
Aim: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. Methods: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 partici...
Introduction: With increasing life expectancy and the rising prevalence of Age-related Macular Degeneration (AMD), one of the leading causes of blindness, a deeper understanding of its pathophysiology is essential to enhance prevention, diagnosis, and treatment. Objective: To compare AMD progression in patients with and without Type 2 Diabetes Mellitus (T2DM) and evaluate vascular and neurodegenerative markers ...
Introduction: While the morphological and functional integrity of the corneal endothelium, which is essential for corneal transparency, is affected by diabetes mellitus (DM), its relationship with the severity of diabetic retinopathy and the presence of diabetic macular edema is unclear. Aims: To assess the morphological characteristics of the corneal endothelium in patients with Type 2 Diabetes Mellitus (T2DM)...
Introdução: Apesar da integridade morfológica e funcional do endotélio corneano, essencial para a transparência corneana, ser afetada com a Diabetes Mellitus (DM) a sua relação com severidade de retinopatia diabética e presença de edema macular diabético não é clara. Objetivos: Avaliar as características morfológicas do endotélio corneano em doentes com Diabetes Mellitus Tipo 2 (DMT2) com diferentes perfis de r...
Introduction – Pars Plana Vitrectomy (PPV) is a vitreoretinal surgical technique that allows access to the posterior eye segment, enabling its treatment. It is, currently, the gold standard treatment for pathologies such as epiretinal membrane (ERM) and macular hole (MH), and is usually accompanied by the peeling of the inner limiting membrane (ILM), a boundary structure between the retina and the vitreous, eli...
OCT-A is an exam that allows visualization of the retinal and choroidal vascularization as well as the three-dimensional visualization of the vascular plexuses at different depths, providing functional information about the blood flow in the vessels, and areas of non-perfusion or neovascularization. The foveal avascular zone corresponds to an area deprived of capillaries in the foveolar region that can be detec...
The recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosomal instability and aneuploidy, which contributes to the accumulation of genetic abnormalities and tumorigenesis. NO...
Purpose: DNA methylation is involved in Diabetic Retinopathy progression showing a metabolic memory mechanism. However, the association of DNA methyltransferase with diabetic macular edema is still unknown. We aimed to describe the differences in DNA methyltransferase gene expression in patients with different diabetic macular edema responses. Methods: A total of 27 diabetic patients, aged 59-90 years, were pro...