6 documents found, page 1 of 1
Nanoencapsulation of gla-rich protein (GRP) as a novel approach to target infla...
Viegas, Carla S. B.; Araújo, Nuna; Carreira, Joana; Pontes, Jorge F.; Macedo, Anjos L.; Vinhas, Maurícia; Moreira, Ana S.; Faria, Tiago Q.; Grenha, AnaChronic inflammation is a major driver of chronic inflammatory diseases (CIDs), with a tremendous impact worldwide. Besides its function as a pathological calcification inhibitor, vitamin K-dependent protein Gla-rich protein (GRP) was shown to act as an anti-inflammatory agent independently of its gamma-carboxylation status. Although GRP’s therapeutic potential has been highlighted, its low solubility at physio...
Nanoencapsulation of Gla-Rich Protein (GRP) as a novel approach to target infla...
Viegas, Carla; Araújo, Nuna; Carreira, Joana; Pontes, Jorge Filipe; Macedo, Anjos L.; Vinhas, Maurícia; Moreira, Ana S.; Faria, Tiago Q.; Grenha, AnaChronic inflammation is a major driver of chronic inflammatory diseases (CIDs), with a tremendous impact worldwide. Besides its function as a pathological calcification inhibitor, vitamin K-dependent protein Gla-rich protein (GRP) was shown to act as an anti-inflammatory agent independently of its gamma-carboxylation status. Although GRP’s therapeutic potential has been highlighted, its low solubility at physio...
Transthoracic echocardiography reference values in juvenile and adult 129/Sv mice
Vinhas, Maurícia; Araújo, Ana Carolina; Ribeiro, Sónia; Rosário, Luís Brás; Belo, José AntónioBackground: In the recent years, the use of Doppler-echocardiography has become a standard non-invasive technique in the analysis of cardiac malformations in genetically modified mice. Therefore, normal values have to be established for the most commonly used inbred strains in whose genetic background those mutations are generated. Here we provide reference values for transthoracic echocardiography measurements...
Transthoracic echocardiography reference values in juvenile and adult 129/Sv mice
Vinhas, Maurícia; Araújo, Ana Carolina; Ribeiro, Sónia; Rosário, Luís Brás; Belo, José A.Background In the recent years, the use of Doppler-echocardiography has become a standard non-invasive technique in the analysis of cardiac malformations in genetically modified mice. Therefore, normal values have to be established for the most commonly used inbred strains in whose genetic background those mutations are generated. Here we provide reference values for transthoracic echocardiography measurements ...
Circadian clock genes Bmal1 and Clock during early chick development
Gonçalves, Lisa; Vinhas, Maurícia; Pereira, Rui; Pais De Azevedo, Tomás; Bajanca, Fernanda; Palmeirim, IsabelBackground: The circadian clock is a well‐described temporal organizer in adult organisms. Despite the particularly evident need for temporal control during embryo development, the effect of environmental cues is still greatly neglected. Few studies have reported circadian clock gene expression in early embryonic stages. However, nothing is known about circadian clock gene expression and function in the first s...
Role of the different actin genes during extrusion of capping protein mutant ce...
Vinhas, MauríciaO citosqueleto da actina é constituido por um enorme número de proteínas e mecanismos regulatórios que estão envolvidos na polimerização, depolimerização e organização dos filamentos de actina. Por esta razão, este sistema é vulnerável a alterações genéticas que podem vir a causar determinadas doenças, tais como o cancro. Nas células cancerígenas, as perturbações estruturais e funcionais do citosqueleto de acti...