3 documents found, page 1 of 1
A Novel BCR-ABL1 Mutation in a Patient with Philadelphia Chromosome-Positive B-...
Vinhas, R; Lourenço, A; Santos, S; Lemos, M; Ribeiro, P; Botelho de Sousa, A; Viana Baptista, P; Ramos Fernandes, APhiladelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) represents the most common genetic subtype of adult ALL (20%-30%) and accounts for approximately 50% of all cases in the elderly. It has been considered the subgroup of ALL with the worst outcome. The introduction of tyrosine kinase inhibitors (TKIs) allows complete hematologic remission virtually in all patients, with improved disease-free...
A Double Philadelphia Chromosome-Positive Chronic Myeloid Leukemia Patient, Co-...
Vinhas, R; Lourenço, A; Santos, S; Ribeiro, P; Silva, M; Botelho de Sousa, A; Baptista, P; Fernandes, A
Colorimetric Assessment of BCR-ABL1 Transcripts in Clinical Samples Via Gold Na...
Vinhas, R; Correia, C; Ribeiro, P; Lourenço, A; Botelho de Sousa, A; Fernandes, A; Baptista, PGold nanoparticles functionalized with thiolated oligonucleotides (Au-nanoprobes) have been used in a range of applications for the detection of bioanalytes of interest, from ions to proteins and DNA targets. These detection strategies are based on the unique optical properties of gold nanoparticles, in particular, the intense color that is subject to modulation by modification of the medium dieletric. Au-nanop...