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Mineralocorticoid receptor antagonists eplerenone and spironolactone modify adr...

Pereira, SS; Carvalho, LS; Costa, MM; Melo, A; Ferreira, IMPLVO; Gomez-Sanchez, CE; Monteiro, MP; Vinson, G; Pignatelli, D

Mineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR, n = 18) and normotensive rats (WKY, n = 18) were randomly exposed to a daily dose of spironolactone (n = 6), eple...

Date: 2021   |   Origin: Repositório Aberto da Universidade do Porto
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