3 documents found, page 1 of 1
Unlocking the role of metabolic pathways in brain metastatic disease
Pinto, Madalena; Violante, Sara; Cascao, Rita; Faria, ClaudiaThe dissemination of malignant cells to the brain is a late-stage complication of cancer, leading to significant morbidity and mortality. Brain metastases (BM) affect 20-30% of cancer patients, primarily originating from lung cancer, breast cancer, and melanoma. Despite advances in molecular-targeted therapies, brain metastatic disease remains incurable, with a poor median survival of ≤12 months if left untreat...
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in P...
Martins, Madalena; Rosa, Alexandra; Guedes, Leonor C.; Fonseca, Benedita V.; Gotovac, Kristina; Violante, Sara; Mestre, Tiago; Coelho, MiguelmiRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson’s disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in neuronal patterning and cell specification. To further investigate their involvement in the etiology of PD, we conducted miRNA expression profiling in peripheral b...
Heterologous expression and purification of human carnitine acylcarnitine trans...
Ventura, Fátima V; Violante, Sara; Jorge, Ana Maria; Gaspar, Maria Manuela; Cruz, Maria Eugénia; Doveral, Graça; Leandro, Paula