7 documents found, page 1 of 1
Detection of the SARS-CoV-2 UK variant in Portugal
Bandarra, Susana; Monteiro, Lurdes; Brum, LauraAt the end of 2020, a new highly transmissible variant of SARS-CoV-2 was discovered in the United Kingdom (UK). This work aims to identify potential cases of the UK variant in Portugal using routine diagnostic samples. A total of 26 out of 43 positive samples that were identified by RT-PCR as suspects were confirmed through sequencing to be the SARS-CoV-2 UK variant. The first case of the UK variant identified ...
Using genomics to understand the origin and dispersion of multidrug and extensi...
Perdigão, João; Gomes, Pedro; Miranda, Anabela; Maltez, Fernando; Machado, Diana; Silva, Carla; Phelan, Jody E.; Brum, Laura; Campino, SusanaPortugal is a low incidence country for tuberculosis (TB) disease. Now figuring among TB low incidence countries, it has since the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predominantly by two strain-types: Lisboa3 and Q1. This study describes the largest characterization of the evolutionary trajectory of M/XDR-TB strains in Portugal, spanning a time-period of two...
Environment and Health in Children Day Care Centres
Neuparth, Nuno; Papoila, Ana Luísa; Aelenei, Daniel; Cano, Manuela; Paixão, Paulo; Viegas, João; Martins, Pedro; Araújo Martins, JoséThis project addresses a set of common clinical problems in the context of children attending day care centres. It is common sense that children get sick more often as soon as they start attending a day care centre on a daily basis and this is particularly true for some groups at risk, as wheezing infants and wheezing pre-school children. Concerning this, some questions remain unclear: 1. The role of indoor air...
Genetic characterisation of the ethambutol resistance-determining region in Myc...
Perdigao, Joao; Macedo, Rita; Ribeiro, Ana; Brum, Laura; Portugal, IsabelEthambutol (EMB) is a first-line antitubercular drug that inhibits arabinogalactan and lipoarabinomannan biosynthesis. Resistance to EMB has traditionally been associated with embB mutations, especially in the Met306 codon. In this study, the region encom. - Fundacao Calouste Gulbenkian, Lisbon, Portugal [FCG 001013]. - Funding: This work was supported by Fundacao Calouste Gulbenkian, Lisbon, Portugal (grant FC...
Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospita...
Perdigao, Joao; Milho, Catarina; Carrilho, Lurdes; Brum, Laura; Portugal, IsabelPortugal has one of the highest tuberculosis notification rates of the European Union with Lisbon Health Region having an incidence rate well above the national average. The present study analyses the transmission, drug susceptibility and characteristics. - Fundacao para a Ciencia e Tecnologia [POCTI/ESP/42941/2001]. - This work was supported by Fundacao para a Ciencia e Tecnologia (FCT grant POCTI/ESP/42941/20...
Molecular epidemiology of Mycobacterium tuberculosis in Lisbon
Portugal, Isabel; Barreiro, Luis; Vultos, Tiago; Macedo, Rita; Furtado, Cristina; Antunes, Antonio Fonseca; Brum, LauraWe conducted a molecular epidemiology study of mycobacterium tuberculosis strains isolated from patients in Lisbon hospitals. We used restriction fragment length polymorphism (RFLP) to detect Lisbon family strains and to determine the genetic diversity of
Multidrug-resistant tuberculosis in Lisbon, Portugal
Perdigao, Joao; Macedo, Rita; Joao, Ines; Fernandes, Elisabete; Brum, Laura; Portugal, IsabelPortugal has the fourth highest tuberculosis (TB) incidence rate in the European Union (EU). Thirty-nine percent of all cases originate in Lisbon Health Region. Portugal also presents high levels of multidrug-resistant tuberculosis (MDR-TB) (1.5%, primary