2 documents found, page 1 of 1
Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir an...
Costa, T; Ribeiro, A; Machado, R; Ribeiro, C; Lanceros-Mendez, S; Cavaco-Paulo, A; Almeida, A; Neves, J; Lúcio, M; Viseu, THerpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to lea...
Rational development of liposomal hydrogels: A strategy for topical vaginal ant...
Faria, M; Machado, R; Ribeiro, A; Gonçalves, H; Oliveira, ME; Viseu, T; Neves, J; Lúcio, MHIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), in silico and in vitro studies were performed to evaluate the physicochemical characteristics of both drugs, and to study their biophysical impact in lipid model system...