5 documents found, page 1 of 1
Antimicrobial activity of prophage endolysins against critical Enterobacteriace...
Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luis; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M. B.; Caniça, ManuelaEnterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...
Antimicrobial activity of prophage endolysins against critical Enterobacteriace...
Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luis; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M.B.; Caniça, ManuelaEnterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...
Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aerugin...
Morais, Diana; Tanoeiro, Luis; Marques, Andreia T.; Gonçalves, Tiago; Duarte, Aida; Matos, António Pedro Alves; Vital, Joana S.Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium that presents resistance to several antibiotics, thus, representing a major threat to human and animal health. Phage-derived products, namely lysins, or peptidoglycan-hydrolyzing enzymes, can be an effective weapon against antibiotic-resistant bacteria. Whereas in Gram-positive bacteria, lysis from without is facilitated by the exposed peptidogly...
Biomarker Characterization and Prediction of Virulence and Antibiotic Resistanc...
Vital, Joana S.; Tanoeiro, Luis; Lopes-Oliveira, Ricardo; Vale, Filipa F.The Gram-negative bacterium Helicobacter pylori colonizes c.a. 50% of human stomachs worldwide and is the major risk factor for gastric adenocarcinoma. Its high genetic variability makes it difficult to identify biomarkers of early stages of infection that can reliably predict its outcome. Moreover, the increasing antibiotic resistance found in H. pylori defies therapy, constituting a major human health problem...
Liposomal delivery of newly identified prophage lysins in a Pseudomonas aerugin...
Morais, Diana; Tanoeiro, Luís; Marques, Andreia T.; Gonçalves, Tiago; Duarte, Aida; Matos, António Pedro Alves; Vital, Joana S.Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium that presents resistance to several antibiotics, thus, representing a major threat to human and animal health. Phage-derived products, namely lysins, or peptidoglycan-hydrolyzing enzymes, can be an effective weapon against antibiotic-resistant bacteria. Whereas in Gram-positive bacteria, lysis from without is facilitated by the exposed peptidogly...