9 documents found, page 1 of 1
Organizational identifiers in the portuguese scientific ecosystem: the transiti...
Harb-Anger, Talissa; Melo-Dias, Sara; Laranjeira, Cátia; Lopes, Pedro Leitão; Moreira, João MendesOpen Science has driven significant changes in the management and sharing of scientific information. In Portugal, the PTCRIS program plays a central role in implementing national and European policies, promoting interoperability through persistent identifiers. Since 2016, the ISNI+ system, which combines the ISNI infrastructure with commercial services from CCC – Ringgold Solutions, has been used to identify or...
Responsiveness to pulmonary rehabilitation in COPD is associated with changes i...
Melo-Dias, Sara; Cabral, Miguel; Furtado, Andreia; Souto-Miranda, Sara; Mendes, Maria Aurora; Cravo, João; Almeida, Catarina Rodrigues; Marques, AldaBackground Pulmonary Rehabilitation (PR) is one of the most cost-effective therapies for chronic obstructive pulmonary disease (COPD) management. There are, however, people who do not respond to PR and reasons for non-response are mostly unknown. PR is likely to change the airway microbiota and this could play a role in its responsiveness. In this study we have explored the association between PR effectiveness ...
Saliva as a non-invasive specimen for COPD assessment
Melo-Dias, Sara; Valente, Carla; Andrade, Lília; Marques, Alda; Sousa, AnaBackground: People with COPD have been reported to bear a distinct airway microbiota from healthy individuals based on bronchoalveolar lavage (BAL) and sputum samples. Unfortunately, the collection of these samples involves relatively invasive procedures and is resource-demanding, limiting its regular use. Non-invasive samples from the upper airways could constitute an interesting alternative, but its relations...
The effectiveness of pulmonary rehabilitation in COPD is associated with specif...
Melo-Dias, Sara; Cabral, Miguel; Furtado, Andreia; Souto-Miranda, Sara; Almeida, Catarina; Marques, Alda; Sousa, AnaPulmonary Rehabilitation (PR) is the most cost-effective therapy for chronic obstructive pulmonary disease (COPD), but not all patients are responsive. The reasons behind this and the role of the airway microbiota in PR effectiveness are currently unknown. Here, we explored the effects of PR on oral microbiota and inflammatory markers and the associations of observed changes with responsiveness to PR. 456 saliv...
Salivary microbiota composition is associated with severe exacerbations
Melo-Dias, Sara; Valente, Carla; Andrade, Lília; Marques, Alda; Sousa, AnaPeople with COPD present microbiota dysbiosis. Clinical implications of this finding are still unknown and need validation. Here, we tested the association between salivary microbiota and COPD and its ability to discriminate different types of patients. 67 patients with COPD (57male, 68±9y, FEV1pp 48±19, GOLD A-12, B-31, C-5, D-19) were characterised based on sociodemographic, anthropometric, clinical data and ...
Saliva as a “patient-friendly” specimen for COPD assessment
Sousa, Ana; Melo-Dias, Sara; Valente, Carla; Andrade, Lília; Marques, AldaBronchoalveolar lavage (BAL) and sputum samples are commony used to provide valuable information on airway microbiota of COPD but they are too invasive to be routinely collected. An interesting alternative would be the use of non-invasive samples from the upper airways but its validation is still lacking. Here, we have explored the merits of saliva to identify the typical profile of COPD microbiota. 70 patients...
Patients’ perspectives on exposure to environmental contaminants: a missing pie...
Souto-Miranda, Sara; Melo-Dias, Sara; Valente, Carla; Freitas, Célia; Sousa, Ana Margarida; Sousa, Ana Catarina; Marques, AldaChronic obstructive pulmonary disease (COPD) is influenced by environmental factors, such as indoor/outdoor contaminants. However, patients’ views on environmental exposure are little-known and this is an often-neglected topic in psychoeducational sessions in pulmonary rehabilitation (PR). We explored the views of patients with COPD about indoor/outdoor environment and its influence on their health and the impa...
Exploring salivary microbiota as a COPD biomarker
Melo-Dias, Sara; Tavares, Ana Helena; Valente, Carla; Andrade, Lília; Marques, Alda; Sousa, AnaBackground: Evidence of the clinical implications of microbiota dysbiosis in chronic obstructive pulmonary disease (COPD) is still lacking, needs validation and is fundamental as microbiota might be a promising biomarker of this disease. We aimed at exploring saliva’s microbiota of patients with COPD to query its relationship with disease-specific clinical parameters and evaluate its potential to be used as a C...
Could salivary microbiota be used as a COPD biomarker?
Melo-Dias, Sara; Tavares, Ana Helena; Valente, Carla; Andrade, Lília; Almeida, Catarina; Marques, Alda; Sousa, AnaBackground: Chronic Obstructive Pulmonary Disease (COPD), an inflammatory disease of the airways with high morbidity and mortality (3rd leading cause of death worldwide), is highly heterogeneous in terms of clinical phenotype being very difficult to treat and manage [1–3]. Precision Medicine holds great promise for this type of diseases but relies on the existence of validated biomarkers for disease prognosis o...