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ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric ...
Oriá, Reinaldo B.; Freitas, Raul S.; Roque, Cássia R.; Nascimento, José Carlos R; Silva, Ana Paula; Malva, João O.; Guerrant, Richard L.Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the ...
Apolipoprotein E plays a key role against cryptosporidial infection in transgen...
Azevedo, Orleâncio G. R.; Bolick, David T.; Roche, James K.; Pinkerton, Relana F.; Lima, Aldo A. M.; Vitek, Michael P.; Warren, Cirle A.Apolipoliprotein E (apoE), a critical targeting protein in lipid homeostasis, has been found to have immunoinflammatory effects on murine models of infection and malnutrition. The effects of apoE in undernourished and Cryptosporidium parvuminfected mice have not been investigated. In order to study the role of apoE in a model of C. parvum infection, we used the following C57BL6J mouse genetic strains: APOE-defi...