24 documents found, page 1 of 3

Chrono-nutrition and post-bariatric weight loss: insights from the Portuguese C...

Background: Post-bariatric weight loss varies substantially, and a large proportion of patients respond poorly. The literature highlights the importance of chrono-nutrition for weight regulation. This study aims to explore the chrono-related factors associated with poorer weight loss. Methods: This study was conducted within the ChronoWise project, an ongoing prospective cohort study following patients undergoi...

Engineering arabinose-to-arabitol conversion in industrial Saccharomyces cerevi...

Arabitol, a promising low-calorie sweetener for the food industry, faces production challenges due to the high costs and the environmental impact of conventional chemical methods, as well as the inefficiency of biological approaches using native arabitol-producing yeasts. The Saccharomyces cerevisiae GRE3 gene encodes an NADPH-dependent aldose reductase, capable of converting various aldoses to their respective...

Structural characterization of the Aspergillus niger citrate transporter CexA u...

The Aspergillus niger CexA transporter belongs to the DHA1 (Drug-H+ antiporter) family. CexA homologs are exclusively found in eukaryotic genomes, and CexA is the sole citrate exporter to have been functionally characterized in this family so far. In the present work, we expressed CexA in Saccharomyces cerevisiae, demonstrating its ability to bind isocitric acid, and import citrate at pH 5.5 with low affinity. ...

Molecular characterization of thyroid tumors of dogs – a multicentric Portugues...

Background: The incidence of thyroid carcinoma (TC) in human population has been increasing worldwide, and it was estimated an incidence of 2.1% of cancer new cases in 2019 [1]. A smaller incidence is reported for canine population (1.1%) in 1995-2005 [2]. Diagnosis, prognosis, and management of human TC rely on mutation screening of BRAF, RAS genes, and TERT promoter. BRAF, NRAS, HRAS, and KRAS encode proteins...

A temporal analysis on patient and health service delays in pulmonary tuberculo...

Background: Tuberculosis (TB) diagnosis and treatment delays increase the period of infectiousness, making TB control difficult and increasing the fatality rates. This study aimed to determine the evolution of health care service delay (time between the patient’s first contact with the health service and the diagnosis/start of treatment) and patient delay (time between onset symptoms date and the date of first ...

Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: R...

Background: The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been increasing in the last five decades, but there is no large-scale data regarding these tumours in Portugal. We conducted a cross-sectional, multicentric study in main Portuguese centers to evaluate the clinical, pathological, and therapeutic profile of GEP-NENs. Methods: From November, 2012, to July, 2014, data from ...

Importance of pathway selection in recombinant xylose-consuming Saccharomyces c...

Xylose fermentation efficiency of industrial Saccharomyces cerevisiae yeast wit...

Xylose isomerase (XI) and xylose reductase/xylitol dehydrogenase (XR/XDH) pathways have been extensively used to confer xylose assimilation capacity to Saccharomyces cerevisiae and tackle one of the major bottlenecks in the attainment of economically viable lignocellulosic ethanol production. Nevertheless, there is a lack of studies comparing the efficiency of those pathways both separately and combined. In thi...

New designsns of solar collectors for heterogeneous TiO2 photocatalytic processes

Solar hardware design for photocatalytic processes includes aspects of optics, geometry and reactor materials. Compound parabolic collectors (CPCs) have widely been used to promote heterogeneous and homogeneous photocatalytic reactions. In this work, different reflective surface (RS) materials (anodized aluminum with [MS] and without [R85] protective coating, soiled aluminum [R85s] and stainless steel [SS]) and...

Assembling and auditing a comprehensive DNA barcode reference library for Europ...

A large-scale comprehensive reference library of DNA barcodes for European marine fishes was assembled, allowing the evaluation of taxonomic uncertainties and species genetic diversity that were otherwise hidden in geographically restricted studies. A total of 4118 DNA barcodes were assigned to 358 species generating 366 Barcode Index Numbers (BIN). Initial examination revealed as much as 141 BIN discordances (...