6 documents found, page 1 of 1
Influence of HER2 expression on prognosis in metastatic triple-negative breast ...
Gampenrieder, SP; Dezentjé, V; Lambertini, M; de Nonneville, A; Marhold, M; Le Du, F; Cortés Salgado, A; Alpuim Costa, D; Vaz Batista, M; Chic Ruché, NBackground: Triple-negative breast cancer (TNBC) is associated with poor prognosis, and new treatment options are urgently needed. About 34%-39% of primary TNBCs show a low expression of human epidermal growth factor receptor 2 (HER2-low), which is a target for new anti-HER2 drugs. However, little is known about the frequency and the prognostic value of HER2-low in metastatic TNBC. Patients and methods: We retr...
Local Breast Microbiota: A “New” Player on the Block
Vitorino, M; Alpuim Costa, D; Vicente, R; Caleça, T; Santos, CThe tumour microenvironment (TME) comprises a complex ecosystem of different cell types, including immune cells, cells of the vasculature and lymphatic system, cancer-associated fibroblasts, pericytes, and adipocytes. Cancer proliferation, invasion, metastasis, drug resistance and immune escape are all influenced by the dynamic interaction between cancer cells and TME. Microbes, such as bacteria, fungi, viruses...
Mutation Patterns in Portuguese Families with Hereditary Breast and Ovarian Can...
Vicente, R; Alpuim Costa, D; Vitorino, M; Mendes, AD; Santos, C; Fontes-Sousa, MGermline pathogenic variants in the Breast Cancer Genes 1 (BRCA1) and 2 (BRCA2) are responsible for Hereditary Breast and Ovarian Cancer (HBOC) syndrome. Genetic susceptibility to breast cancer accounts for 5-10% of all cases, phenotypically presenting with characteristics such as an autosomal dominant inheritance pattern, earlier age of onset, bilateral tumours, male breast cancer, and ovarian tumours, among o...
Human Microbiota and Immunotherapy in Breast Cancer - A Review of Recent Develo...
Vitorino, M; Baptista de Almeida, S; Alpuim Costa, D; Faria, A; Calhau, C; Azambuja Braga, SBreast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Infectious agents are the third most important risk factor for cancer incidence after tobacco and obesity. Dysbiosis emerged as a key player that may influence cancer development, treatment, and prognosis through diverse biological processes. Metastatic BC has a highly variable cli...
Case Report: Pure Red Cell Aplasia due to Angioimmunoblastic T-Cell Lymphoma.
Vitorino, M; Nunes, F; Costa, M; Porteiro, B; Borges, A; Machado, JPure red cell aplasia (PRCA) is a rare bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leukopenia and thrombocytopenia. It can be associated with various hematological disorders but exceedingly rarely with angioimmunoblastic T-cell lymphoma (AITL). We report the case of a 72-year-old woman with PRCA associated with AITL. The patient presented with severe anemia...
Epidural Abscess Related to Brucellar Spondylodiscitis Diagnosis by Polymerase ...
Costa, M; Vitorino, M; Porteiro, B; Pedro, W; Major, M; Machado, JThe localized forms of brucellosis, particularly osteoarticular, by their symptomatology usually nonspecific, still continue to be a diagnosis challenge, being fundamental to raise a high degree of suspicion based on a careful epidemiological history. The authors describe the case of a 69 year old farmer that was admitted due to an insidious lower back pain with irradiation to the left lower limb accompanied by...