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The influence of glutathione pathway modulators on the cytotoxicity of sunitini...
Vitorino-Oliveira, C.; Kahremany, S.; Nisim, L.; Duarte-Araújo, M.; Carvalho, F.; Gruzman, A.; Costa, V. M.Background: Cancer survivorship has grown over the years due to more efficacious treatments. Nonetheless, anticancer treatments present serious adverse effects, namely cardiotoxicity. Doxorubicin (DOX), a topoisomerase II inhibitor; sunitinib (SUN), a multikinase inhibitor; and bortezomib (BTZ), an inhibitor of proteasome, have their clinical use limited because of their cardiotoxicity. Cardiotoxicity is often ...
Date: 2023
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Origin: Scientific Letters