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Evaluation of Amlodipine and Imipramine Efficacy to Treat Galleria mellonella I...

Andrade, Mariana; Neves, Joana; Bento, Maria; Marques, Joana; Seabra, Sofia G.; Silveira, Henrique; Rodrigues, Liliana; Armada, Ana; Viveiros, Miguel

Funding Information: This work was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020, to the Project DREBI, Ref. 2022.07931.PTDC (DOI: 10.54499/2022.07931.PTDC), to the grants of M.A. (UI/BD/154472/2022) and J.N. (2022.07931.PTDC), and to the contracts of J.M. (DOI: 10.54499/CEECIND/00450/2017/CP1415/CT0001),...


Unlocking the Gates

Patil, Mrunal; Munteanu, Tatiana; Brasseur, Gaël; Ferreira, Carolina; Costa, Sofia Santos; Couto, Isabel; Athar, Mohd; Asunis, Elisa

Funding Information: All authors contributed equally to this work. This project was partially funded by the A*Midex Foundation Interdisciplinarity Grant \u201CElisa.\u201D M.P. was supported by the CNRS\u2010Innovation \u201CPhenux\u201D Grant. M.A. and A.V.V. gratefully acknowledge the \u201COne Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases (INF\u2010ACT...


Molecular Patterns and Antimicrobial Resistance Characterization of Salmonella ...

Francisco, Moisés; Belas, Adriana; Costa, Sofia Santos; Menezes, Juliana; Ramos, Jorge; Couto, Isabel; Viveiros, Miguel; Pomba, Constança

This research was supported by Fundação para a Ciência e a Tecnologia (FCT, Portugal) through funds to GHTM—UIDP/04413/2020, LA-REAL—LA/P/0117/2020, CIISA and AL4AnimalS (UIDB/00276/2020 and LA/P/0059/2020, respectively). J.M. was supported by a PhD fellowship (2020.07562.BD). S.S.C. was supported by FCT through CEECINST/00042/2021/CP1773/CT0009 (https://doi.org/10.54499/CEECINST/00042/2021/CP1773/CT0009).; The...


Galleria mellonella research hub

Andrade, Mariana; Neves, Joana; Marques, Joana; Armada, Ana; Rodrigues, Liliana; Viveiros, Miguel; Silveira, Henrique; Couto, Isabel

Fundação para a Ciência e a Tecnologia through funds to DREBI Project Ref. 2022.07931. PTDC (doi: 10.54499/2022.07931.PTDC); GHTM (UID/04413/2020); LA-REAL (LA/P/0117/2020); UI/BD/154472/2022 (MA); 2022.07931.PTDC (JN) and CEECINST/00042/2021/CP1773/CT0009 (SSC); Galleria mellonella represents a sustainable invertebrate infection model that is gaining interest for pathogenicity and infection, host-pathogen inte...


Galleria mellonella

Andrade, Mariana; Neves, Joana; Bento, Maria; Marques, Joana; Viveiros, Miguel; Rodrigues, Liliana; Armada, Ana; Silveira, Henrique; Couto, Isabel

Financiamento: Fundação para a Ciência e a Tecnologia (FCT), Portugal, através de fundos para o Projeto DREBI Ref. 2022.07931.PTDC; GHTM (UID/04413/2020); LA-REAL (LA/P/0117/2020); Bolsa de doutoramento UI/BD/154472/2022 (MA); bolsa de BI 2022.07931.PTDC (JN) e CEECINST/00042/2021/CP1773/CT0009 (SSC); Galleria mellonella é um modelo larval de infeção que tem ganho destaque na comunidade científica para a avalia...


The performance of Xpert MTB/RIF and MTBDRplus within a Programmatic setting at...

Malaquias, Thiago da Silva Santos; Ribeiro, Eunice Petris; Dutra, Tatiana Cristina Pereira; Ricardo, Marina; Salvato, Richard; Bhering, Marcela

This research was funded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) /INCT; grant number - 421703/2017-2.; BACKGROUND: Few studies in routine settings have confirmed the high accuracy of the Xpert MTB/RIF assay for detecting rifampicin resistance (RR) and the first-line probe assay (FL-LPA) for detecting both RR and isoniazid resistance (INHR). METHODS: The performance of Xpert MTB/R...


Antimicrobial resistance, society and environment

Ferrinho, Paulo; Viveiros, Miguel; Fronteira, Inês

Funding Information: GHTM ( UID/Multi/04413/2019 ) is Funded by the Portuguese Science Foundation (FCT).


Towards clinical breakpoints for non-tuberculous mycobacteria – Determination o...

EUCAST AMST study group; ESCMYC study group; Viveiros, Miguel; Machado, Diana

Funding Information: FPM; Mukoviszidose Institut gGmbH, Bonn, the German Cystic Fibrosis Association Mukoviszidose e.V. TS; Swedish Heart and Lung Foundation and the Swedish research council. Funding Information: The Clinical and Laboratory Standards Institute (CLSI) recommends using broth microdilution (BMD) in cation adjusted Mueller Hinton broth (CAMHB) for AST of most NTM [10,11]. There is limited data in s...


Occurence and variability of norA and other main multidrug efflux pump determin...

Ferreira, Carolina; Abrantes, Patrícia; Costa, Sofia Santos; Viveiros, Miguel; Couto, Isabel

Background Multidrug efflux pumps (MDR EPs) play a major role in the emergence of antimicrobial resistance (AMR). NorA is one of the main native MDR EPs of Staphylococcus aureus, contributing to reduced susceptibility towards fluoroquinolones and biocides[1,2]. In S. aureus, its gene occurs in several allelic variants[3], but less is known about the occurrence of norA and other MDR EPs across the Staphylococcus...


Implementation of a Galleria mellonella infection model at GHTM/IHMT-NOVA

Rodrigues, Telma; Andrade, Mariana; Marques, Joana; Rodrigues, Liliana; Viveiros, Miguel; Silveira, Henrique; Couto, Isabel; Costa, Sofia Santos


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