14 documents found, page 1 of 2

Metabolic profiling of maternal urine can aid clinical management of gestationa...

Introduction The clinical management of Gestational diabetes mellitus (GDM) would benefit from enhanced metabolic knowledge both at the time of diagnosis and during therapy. Objectives This work aimed at unveiling metabolic markers of GDM and of the subjects' response to therapy. Methods Urine NMR metabolomics was used with a variable selection methodology to reduce uninformative variability. The NMR data was a...

Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signatur...

RCC usually develops and progresses asymptomatically and, when detected, it is frequently at advanced stages and metastatic, entailing a dismal prognosis. Therefore, there is an obvious demand for new strategies enabling an earlier diagnosis. The importance of metabolic rearrangements for carcinogenesis unlocked a new approach for cancer research, catalyzing the increased use of metabolomics. The present study ...

Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case...

This work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consider...

Quantification of 3-deoxyglucosone (3DG) as an aging marker in natural and forc...

The Maillard reaction product 3-deoxyglucosone (3DG) was quantified in wines, by high-performance liquid chromatography-mass spectrometry analysis after derivatization with ortho-phenylenediamine. Both sweet red Port wines and dry white wines were analysed during natural and forced aging. In natural aging, and for dry white wines, 3DG is negatively correlated to age (r=0.939), while for sweet red Port wines, 3D...

Following Healthy Pregnancy by NMR Metabolomics of Plasma and Correlation to Urine

This work presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy was confirmed with six amino acids being identified as required by the fetus in larger extents. Newly observed changes in citrate, lactate, and dimethyl sulfone suggested early adjustments in energ...

Prediction of Gestational Diabetes through NMR Metabolomics of Maternal Blood

Metabolic biomarkers of pre- and postdiagnosis gestational diabetes mellitus (GDM) were sought, using nuclear magnetic resonance (NMR) metabolomics of maternal plasma and corresponding lipid extracts. Metabolite differences between controls and disease were identified through multivariate analysis of variable selected H-1 NMR spectra. For postdiagnosis GDM, partial least squares regression identified metabolite...

NMR metabolomics of human lung tumours reveals distinct metabolic signatures fo...

NMR metabolomics of lung tissues revealed distinct metabolic signatures for adenocarcinomas and squamous cell carcinomas (the two types being discriminated with a 94% classification rate), thus showing potential for aiding tumours subtyping, a critical diagnostic requirement in lung cancer management.Lung tumour subtyping, particularly the distinction between adenocarcinoma (AdC) and squamous cell carcinoma (Sq...

Urinary metabolomic changes as a predictive biomarker of asthma exacerbation

Changes in the metabolome of lettuce leaves due to exposure to mancozeb pesticide

This paper describes a proton high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) metabolomic study of lettuce (Lactuca sativa L.) leaves to characterise metabolic adaptations during leaf growth and exposure to mancozeb. Metabolite variations were identified through multivariate analysis and checked through spectral integration. Lettuce growth was accompanied by activation of energetic...

Following Healthy Pregnancy by Nuclear Magnetic Resonance (NMR) Metabolic Profi...

In this work, untargeted NMR metabonomics was employed to evaluate the effects of pregnancy on the metabolite composition of maternal urine, thus establishing a control excretory trajectory for healthy pregnancies. Urine was collected for independent groups of healthy nonpregnant and pregnant women (in first, second, third trimesters) and multivariate analysis performed on the corresponding NMR spectra. Models ...