49 documents found, page 1 of 5
Teaching Quality at IHMT-NOVA: monitoring instruments for the period 2019 - 2024
Oliveira Martins, Maria do Rosário; Viveiros, Miguel; Abrantes, PatríciaIntroduction: The evaluation of teaching quality is one of the fundamental components of the Instituto de Higiene e Medicina Tropical da Universidade Nova de Lisboa's (IHMT-NOVA) pedagogical strategy and is anchored in the objectives of the NOVA Quality Council. This article describes the trend of the main Teaching Quality Indicators based on data collected between the 2019/2020 and 2023/2024 academic years at ...
Biomedicine and Artificial Intelligence in Postgraduate Education in Health Sci...
Viveiros, Miguel; Ferreira, Albano; Gonçalves, Mauer; Fortes, FilomenoThe scientific and technological evolution of contemporary medicine demands a new profile of professionals: up-to-date, ethical, multidisciplinary, and prepared to integrate biomedical knowledge with digital tools such as artificial intelligence (AI). NOVA University of Lisbon, Agostinho Neto University from Luanda and Katyavala Bwila University from Benguela have been adapting their educational programmes, pos...
The Microevolutionary Trajectory of Endemic Multidrug-Resistant Tuberculosis St...
Gomes, Pedro; Paixão, Paulo; Maltez, Fernando; Brum, Laura; Phelan, Jody E; Campino, Susana; Clark, Taane G; Viveiros, Miguel; Portugal, IsabelPortugal has one of the highest incidence rates of tuberculosis (TB) in Western Europe and, historically, multidrug-resistant (MDR) cases have been strongly associated with strains pertaining to the endemic Q1 and Lisboa3 clades. Notwithstanding, the contribution of drug resistance-associated allelic configurations in these clades to differing levels of drug resistance and their relationship with drug efficacy ...
Evaluation of T-NGS, Xpert Ultra, and Line Probe Assay on Clinical Samples for ...
Bhering, Marcela; Ribeiro, Eunice Petris; Silveira, Anna Karla; Lalucha, Carolyne; Ribeiro, Elizabete Oliveira; Igreja, Tathiany; Pôrto, Luís CristóvãoBackground: The rapid detection of drug resistance in Mycobacterium tuberculosis is essential for managing drug-resistant tuberculosis (DR-TB). This study evaluated the performance of molecular assays compared to phenotypic drug susceptibility testing (pDST) and targeted next-generation sequencing (T-NGS). Methods: We retrospectively analyzed 40 presumptive pulmonary DR-TB cases in Rio de Janeiro from 2018 to 2...
Activation of nuclear receptors correlates with tuberculosis severity and is a ...
Maceiras, Ana Raquel; Silva, Marta L.; Couto, Joana; Gonçalves, Rute; Silva, Marco; Macedo, Salvador; Machado, Diana; Indafa, Iaia; Sifna, ArmandoIntroduction: The immune response to Mycobacterium tuberculosis is accompanied by metabolic adaptations that fuel host immunity, but that are exploited by the pathogen to ensure persistence and growth. Activation of nuclear receptors, such as liver-X-receptors (LXR), orchestrate macrophage immunometabolic adaptations to infection and globally associate with tuberculosis (TB) protection. Methods: We interrogated...
Efflux systems driving resistance and virulence across biological domains
da Silva, Pedro Eduardo Almeida; Groll, Andrea Von; Ramis, Ivy Bastos; Reis, Ana Julia; Ramos, Daniela Fernandes; Viveiros, MiguelBackground. Efflux pumps (EPs) are key contributors to multidrug resistance (MDR) in bacteria, fungi, and cancer cells. These membrane proteins actively extrude a variety of therapeutic agents, reducing their intracellular concentration and thus compromising the efficacy of treatment. Beyond resistance, EPs are also involved in virulence, biofilm formation, immune evasion, and environmental persistence. Aim. Th...
Determinants of vaccine hesitancy among healthcare workers in an international ...
Drobniewski, Francis; Ashmi, Marcia; Kusuma, Dian; Ahmad, Raheelah; Naumovas, Daniel; Juozapaitė, Dovilė; Toscano, Cristina; Perea, ElviraA total of 2079 healthcare workers (HCWs) responded to an anonymous survey on vaccine hesitancy conducted between December 2022 and October 2023 at centers in Lithuania, Portugal, Poland, Germany, and Brazil. Only 55.7% were confident about the long-term safety of the COVID-19 vaccine; 10% believed the risk of having COVID-19 vaccines was greater than the risk of COVID-19 itself. 54.2% believed that COVID-19 va...
The neglected contribution of streptomycin to the tuberculosis drug resistance ...
Rocha, Deisy M. G. C.; Viveiros, Miguel; Saraiva, Margarida; Osório, Nuno S.The airborne pathogen <i>Mycobacterium tuberculosis</i> is responsible for a present major public health problem worsened by the emergence of drug resistance. <i>M. tuberculosis</i> has acquired and developed streptomycin (STR) resistance mechanisms that have been maintained and transmitted in the population over the last decades. Indeed, STR resistant mutations are frequently identified across the main <i>M. t...
Whole-genome sequencing as a tool for studying the microevolution of drug-resis...
Diniz, Jaciara; von Groll, Andrea; Unis, Gisela; Dalla-Costa, Elis Regina; Rosa Rossetti, Maria Lúcia; Vianna, Júlia Silveira; Ramos, Daniela FernandesTreatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously treated patie...
Genomic-based surveillance reveals high ongoing transmission of multi-drug-resi...
Salvato, Richard Steiner; Reis, Ana Júlia; Schiefelbein, Sun Hee; Gómez, Michael Andrés Abril; Salvato, Stéphanie Steiner; Silva, Larissa Vitória daGenomic-based surveillance on the occurrence of drug resistance and its transmission dynamics has emerged as a powerful tool for the control of tuberculosis (TB). A whole-genome sequencing approach, phenotypic testing and clinical-epidemiological investigation were used to undertake a retrospective population-based study on drug-resistant (DR)-TB in Rio Grande do Sul, the largest state in Southern Brazil. The a...