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Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, Nuno; Sousa, Susana R.; Padrão, Tatiana; Carvalho, Ângela; Lucas, Raquel; Canadas, Raphael F.; Lavrador, Catarina; Alexandre, NunoThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite ...
Coelho, Catarina C.; Padrão, Tatiana; Costa, Laura; Pinto, Marta T .; Costa, Paulo C.; Domingues, Valentina F.; Quadros, Paulo A.; Monteiro, Fernando J.Bone graft infections are serious complications in orthopaedics and the growing resistance to antibiotics is increasing the need for antibacterial strategies. The use of magnesium oxide (MgO) is an interesting alternative since it possesses broad-spectrum antibacterial activity. Additionally, magnesium ions also play a role in bone regeneration, which makes MgO more appealing than other metal oxides. Therefore,...