14 documents found, page 1 of 2
Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Act...
Vojtek, Martin; Martins, Clara B.; Ramos, Raquel; Duarte, Sara Gomes; Ferreira, Isabel M. P. L. V. O.; Carvalho, Ana L. M. Batista deTriple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel drug entities with improved tolerability and selectivity profiles, as w...
Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of ...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Šeminská, Patrícia; Valová, Katarína; Bellón, Loreto; Dias-Pereira, Patrícia; Marques, FranklimPd2Spm is a dinuclear palladium(II)-spermine chelate with promising anticancer properties against triple-negative breast cancer (TNBC), a breast carcinoma subset with poor prognosis and limited treatment options. The present study evaluated the in vitro and in vivo anticancer effects of Pd2Spm compared to the reference metal-based drug cisplatin. Triple-negative breast cancer MDA-MB-231 cells, non-cancerous MCF...
Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of ...
Carneiro, Tatiana J.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Neves, João R.; Carvalho, Ana L. M. Batista de; Marques, Maria Paula M.; Diniz, CarmenThe new palladium agent Pd2Spermine (Spm) has been reported to exhibit promising cytotoxic properties, while potentially circumventing the known disadvantages associated to cisplatin therapeutics, namely acquired resistance and high toxicity. This work presents a nuclear magnetic resonance (NMR) metabolomics study of brain extracts obtained from healthy mice, to assess the metabolic impacts of the new Pd2Spm co...
Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Br...
Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Batista de Carvalho, Ana L. M.; Marques, Maria Paula M.; Diniz, CarmenThe interest in palladium(II) compounds as potential new anticancer drugs has increased in recent years, due to their high toxicity and acquired resistance to platinum(II)-derived agents, namely cisplatin. In fact, palladium complexes with biogenic polyamines (e.g., spermine, Pd2Spm) have been known to display favorable antineoplastic properties against distinct human breast cancer cell lines. This study descri...
Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential An...
Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Diniz, Carmen; Batista de Carvalho, Ana L. M.; Marques, Maria Paula M.Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance. Dinuclear Pd(II) complexes with biogenic polyamines such as spermine (Pd2Spm) have exhibited particularly beneficial cytotoxic properties, hence unveiling the importance of understanding their impact on organism met...
Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinet...
Preclinical pharmacokinetics and biodistribution of Anticancer Dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Carvalho, Ana L. M. Batista dePalladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistri bution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kine...
Preclinical pharmacokinetics and biodistribution of anticancer dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinet...
Novel insights into mice multi-organ metabolism upon exposure to a potential an...
Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Diniz, Carmen; Carvalho, Ana L. M. Batista de; Marques, M. Paula M.Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance. Dinuclear Pd(II) complexes with biogenic polyamines such as spermine (Pd2Spm) have exhibited particularly beneficial cytotoxic properties, hence unveiling the importance of understanding their impact on organism met...
Fast and reliable ICP-MS quantification of palladium and platinum-based drugs i...
Vojtek, Martin; Pinto, Edgar; Gonçalves-Monteiro, Salomé; Almeida, Agostinho; Marques, M. P. M.; Mota-File, Hélder; Ferreira, Isabel M. P. L. V. O.Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matric...