34 documents found, page 1 of 4
Progression of capillary hypoperfusion in advanced stages of nonproliferative d...
Marques, Inês Pereira; Reste-Ferreira, Débora; Santos, Torcato; Mendes, Luís; Yamaguchi, Taffeta Ching Ning; Santos, Ana Rita; Pearce, ElizabethTo evaluate the 6-month progression of retinal capillary perfusion in eyes with advanced stages of nonproliferative diabetic retinopathy (NPDR). Design: RICHARD (NCT05112445), 2-year prospective longitudinal study. Participants: Sixty eyes with Diabetic Retinopathy Severity Scale (DRSS) levels 43, 47, and 53 from 60 patients with type 2 diabetes. Fifty-one patients completed the 6-month evaluation. Eyes were ev...
Patterns of progression of nonproliferative diabetic retinopathy using non-inva...
Marques, Inês Pereira; Ribeiro, Maria Luísa; Santos, Torcato; Reste-Ferreira, Débora; Mendes, Luís; Martinho, António Cunha-Vaz; Santos, Ana RitaTo identify progression of nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes by combining optical coherence tomography angiography (OCTA) metrics and color fundus photography (CFP) images. This study was a post hoc analysis of a prospective longitudinal cohort study (CORDIS, NCT03696810) with 2-year duration. This study enrolled 122 eyes. Ophthalmological examinations included OCTA a...
Intraretinal microvascular abnormalities in eyes with advanced stages of nonpro...
Santos, Ana Rita; Lopes, Marta; Santos, Torcato; Reste‑Ferreira, Débora; Marques, Inês P.; Yamaguchi, Taffeta C. N.; Miranda, Telmo; Mendes, LuísThis study aimed to evaluate intraretinal microvascular abnormalities (IRMA) in eyes with advanced nonproliferative diabetic retinopathy (NPDR) using multimodal approach in co-located areas focusing on central retina (up to 50°) and to look at possible correlations between IRMA and other structural changes, like ischemia and presence of microaneurysms. The RICHARD study (NCT05112445) included 60 eyes from 60 pa...
Central and peripheral involvement of the retina in the initial stages of diabe...
Santos, Ana Rita; Almeida, Ana Catarina; Rocha, Ana Cláudia; Reste-Ferreira, Débora; Marques, Inês Pereira; Martinho, António Cunha-Vaz; Mendes, LuísTo determine the degree of central microvascular closure using optical coherence tomography angiography in eyes of patients with type 2 diabetes with visible lesions only in the central retina or only in the periphery. Cross-sectional study. All 127 eyes underwent ultra-widefield fundus photography 200° examinations with OPTOS California (Optos, Dunfermline, United Kingdom) and Cirrus Angioplex optical coherenc...
ETDRS grading with CLARUS ultra-widefield images shows agreement with 7-fields ...
Santos, Ana Rita; Ghate, Sejal; Lopes, Marta; Rocha, Ana Cláudia; Santos, Torcato; Reste-Ferreira, Débora; Manivannan, Niranchana; Foote, KatharinaTo analyse and compare the grading of diabetic retinopathy (DR) severity level using standard 35° ETDRS 7-fields photography and CLARUS™ 500 ultra-widefield imaging system. A cross-sectional analysis of retinal images of patients with type 2 diabetes (n=160 eyes) was performed for this study. All patients underwent 7-fields colour fundus photography (CFP) at 35° on a standard Topcon TRC50DX® camera, and ultra-w...
Characterisation of progression of macular oedema in the initial stages of diab...
Lobo, Conceição; Santos, Torcato; Marques, Inês; Madeira, Maria H.; Santos, Ana Rita; Figueira, João; Cunha-Vaz, JoséBACKGROUND/OBJECTIVES: To characterise the prevalence and three-year progression of centre-involving diabetic macular oedema (CI-DMO) in minimal to moderate non-proliferative diabetic retinopathy, using optical coherence tomography (OCT) and measurements of retinal fluid using tissue optical reflectivity ratios (OCT-Leakage). METHODS/METHODS: Seventy-four eyes from 74 patients were followed in a 3-year prospect...
Retinal neurodegeneration in eyes with NPDR risk phenotypes: A two-year longitu...
Reste-Ferreira, Débora; Santos, Ana Rita; Marques, Inês Pereira; Santos, Torcato; Ribeiro, Maria Luísa; Mendes, Luís; Santos, Ana Rita; Lobo, ConceiçãoDiabetic retinopathy (DR) is both a microangiopathy and a neurodegenerative disease. However, the connections between both changes are not well known. To characterise the longitudinal retinal ganglion cell layer + inner plexiform layer (GCL + IPL) changes and their association with microvascular changes in type-2 diabetes (T2D) patients with nonproliferative diabetic retinopathy (NPDR). This two-year prospectiv...
Characterization of 2-year progression of different phenotypes of nonproliferat...
Ribeiro, Luísa; Marques, Inês P.; Santos, Torcato; Carvalho, Sara; Santos, Ana Rita; Mendes, Luís; Lobo, Conceição; Cunha-Vaz, JoséThe aim of the study was to characterize the 2-year progression of risk phenotypes of nonproliferative diabetic retinopathy (NPDR) in type 2 diabetes (T2D) phenotype C, or ischemic phenotype, identified by decreased skeletonized retinal vessel density (VD), ≥2 SD over normal values, and phenotype B, or edema phenotype, identified by increased retinal thickness, i.e., subclinical macular edema, and no significan...
Characterisation of progression of macular oedema in the initial stages of diab...
Lobo, Conceição; Santos, Torcato; Marques, Inês P.; Madeira, Maria H.; Santos, Ana Rita; Figueira, João; Cunha-Vaz, JoséTo characterise the prevalence and three-year progression of centre-involving diabetic macular oedema (CI-DMO) in minimal to moderate non-proliferative diabetic retinopathy, using optical coherence tomography (OCT) and measurements of retinal fluid using tissue optical reflectivity ratios (OCT-Leakage). Seventy-four eyes from 74 patients were followed in a 3-year prospective longitudinal observational cohort of...
Retinal capillary nonperfusion in preclinical diabetic retinopathy
Santos, Torcato; Santos, Ana Rita; Almeida, Ana Catarina; Rocha, Ana Cláudia; Reste-Ferreira, Débora; Marques, Inês Pereira; Martinho, António Cunha-VazThe aim of the study was to identify retinal microvascular changes using optical coherence tomography angiography (OCTA) in type 2 diabetes (T2D) patients with preclinical retinopathy identified by ultra-widefield fundus photography (UWF-FP). This is a cross-sectional observational study. All patients underwent UWF-FP 200° examinations with OPTOS California (Optos, Dunfermline, UK) and Cirrus AngioPlex® spectra...