2 documents found, page 1 of 1
Quantification of overdiagnosis in randomised trials of cancer screening
Voss, Theis; Krag, Mikela; Martiny, Frederik; Heleno, Bruno; Jørgensen, Karsten Juhl; Brandt Brodersen, JohnOK; The degree of overdiagnosis in common cancer screening trials is uncertain due to inadequate design of trials, varying definition and methods used to estimate overdiagnosis. Therefore, we aimed to quantify the risk of overdiagnosis for the most widely implemented cancer screening programmes and assess the implications of design limitations and biases in cancer screening trials on the estimates of overdiagno...
Overdiagnosis of lung cancer with low-dose computed tomography screening
Brodersen, John; Voss, Theis; Martiny, Frederik; Siersma, Volkert; Barratt, Alexandra; Heleno, BrunoIn low-dose computed tomography (LDCT) screening for lung cancer, all three main conditions for overdiagnosis in cancer screening are present: 1) a reservoir of slowly or nongrowing lung cancer exists; 2) LDCT is a high-resolution imaging technology with the potential to identify this reservoir; and 3) eligible screening participants have a high risk of dying from causes other than lung cancer. The degree of ov...