The overexpression of P-glycoprotein (P-gp) is often directly related to multidrug resistance (MDR), one of the greatest challenges in cancer treatment. This transmembrane efflux pump decreases the intracellular concentrations of chemotherapy drugs, reducing their effectiveness and resulting in treatment failure. This work used in silico methods to assess the potential of bioactive chemicals produced from mushr...
Chemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for cancer therapies, offering a possible solution to overcome chemoresistance. This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells. We searched the PubMed, Web of Science and...
Internet has changed the way people and brands communicate, produce, share content on social media and buy products or services. Several interaction platforms emerged, making it easy for individuals to exchange information. Facebook and Instagram are the most used networks all over the world; Instagram, in particular, has become one of the social networks with the higher number of followers/users, across differ...
No abstract available.
Introduction: There is no available cutoff for the 1-repetition maximum (1RM) test of knee extensor muscles associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). Aims: To determine 1RM cutoffs for the knee extensors and to verify their association with mortality in COPD. Methods: In a preliminary analysis of a multicenter study, 170 patients performed the 1RM test of knee exte...