2 documents found, page 1 of 1
Chronic stress and glucocorticoids: from neuronal plasticity to neurodegeneration
Vyas, Sheela; Rodrigues, Ana João; Silva, Joana Margarida; Tronche, Francois; Almeida, Osborne F. X.; Sousa, Nuno; Sotiropoulos, I.Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior. Their actions are mediated by glucocorticoid and mineralocorticoid receptors which are nuclear receptors/transcription factors. While GCs primarily act to ma...
Glucocorticoids and neurodegeneration
Vyas, Sheela; Rodrigues, Ana João; Silva, Joana Margarida; Tronche, François; Sousa, Nuno; Sotiropoulos, I.Series: Endocrinology research and clinical developments; Glucocorticoids (GCs) exert wide-spread actions in central nervous system ranging from gene transcription, cellular signaling, modulation of synaptic structure and transmission, glial responses to altered neuronal circuitry and behavior through the activation of two steroid hormone receptors, glucocorticoid receptor (NR3C1, GR) and mineralocorticoid rece...