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Insight into pathogenomics and phylogeography of hypervirulent and highly-letha...
Mokrousov, Igor; Vyazovaya, Anna; Shitikov, Egor; Badleeva, Maria; Belopolskaya, Olesya; Bespiatykh, Dmitry; Gerasimova, Alena; Perdigão, JoãoBackground The Mycobacterium tuberculosis Beijing genotype is globally spread lineage with important medical properties that however vary among its subtypes. M. tuberculosis Beijing 14717-15-cluster was recently discovered as both multidrug-resistant, hypervirulent, and highly-lethal strain circulating in the Far Eastern region of Russia. Here, we aimed to analyze its pathogenomic features and phylogeographic p...
Synthesis, Characterization and Complex Evaluation of Antibacterial Activity an...
Slavchev, Ivaylo M.; Mitrev, Yavor; Shivachev, Boris; Valcheva, Violeta; Dogonadze, Marine; Solovieva, Natalia; Vyazovaya, Anna; Mokrousov, IgorThe synthesis of 20 arylidenecamphors and 15 pyrimidines with camphane skeleton is described in the current report. A modified method for preparation of sterically hindered 2-aminopyrimidines in two steps was demonstrated. The evaluation of their in vitro activity against Mycobacterium tuberculosis H37Rv showed different MIC values (up to 0.91 μM for ketone 39). Compound 35 demonstrated moderate (8.23 μM), but ...
Molecular Insight into Mycobacterium tuberculosis Resistance to Nitrofuranyl Am...
Mokrousov, Igor; Slavchev, Ivaylo; Solovieva, Natalia; Dogonadze, Marine; Vyazovaya, Anna; Valcheva, Violeta; Masharsky, Aleksey; Belopolskaya, OlesyaWe performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain Mycobacterium tuberculosis H37Rv. The most active compound 11 was used for in vitro selection of spontaneous resistant mutants. The same mutations in si...
Practical approach to detection and surveillance of emerging highly resistant M...
Mokrousov, Igor; Vyazovaya, Anna; Sinkov, Viacheslav; Gerasimova, Alena; Ioannidis, Panayotis; Jiao, Weiwei; Khromova, Polina; Papaventsis, DimitriosAncient sublineage of the Mycobacterium tuberculosis Beijing genotype is endemic and prevalent in East Asia and rare in other world regions. While these strains are mainly drug susceptible, we recently identified a novel clonal group Beijing 1071-32 within this sublineage emerging in Siberia, Russia and present in other Russian regions. This cluster included only multi/extensive drug resistant (MDR/XDR) isolate...