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Challenges of the Application of In Vitro Digestion for Nanomaterials Safety As...

Vital, Nádia; Gramacho, Ana Catarina; Silva, Mafalda; Cardoso, Maria; Alvito, Paula; Kranendonk, Michel; Silva, Maria João; Louro, Henriqueta

Publisher Copyright: © 2024 by the authors.; Considering the increase in the production and use of nanomaterials (NM) in food/feed and food contact materials, novel strategies for efficient and sustainable hazard characterization, especially in the early stages of NM development, have been proposed. Some of these strategies encompass the utilization of in vitro simulated digestion prior to cytotoxic and genotox...


Exposure assessment of the European adult population to deoxynivalenol

Namorado, Sónia; Martins, Carla; Ogura, Joana; Assunção, Ricardo; Vasco, Elsa; Appenzeller, Brice; I Halldorsson, Thorhallur; Janasik, Beata

Funding Information: HBM4EU has received funding from the European Union\u2019s research and innovation programme Horizon 2020 under grant agreement No. 733032. The HBM4EU Aligned Studies were co-funded by the European Union\u2019s programme Horizon 2020 through HBM4EU and by the participating countries through the co-authors organizations. Publisher Copyright: © 2024 The Authors; Mycotoxins are natural toxins ...


Harmonized human biomonitoring in European children, teenagers and adults

Govarts, Eva; Gilles, Liese; Rodriguez Martin, Laura; Santonen, Tiina; Apel, Petra; Alvito, Paula; Anastasi, Elena; Andersen, Helle Raun

Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organiz...


How to use human biomonitoring in chemical risk assessment

Santonen, Tiina; Mahiout, Selma; Alvito, Paula; Apel, Petra; Bessems, Jos; Bil, Wieneke; Borges, Teresa; Bose-O'Reilly, Stephan; Buekers, Jurgen

Funding: This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors’ organisations. The results presented here are based on a huge body of work performed as part of Task 5.3 of the HBM4EU in 2017–2022. First and foremost, we would like to acknowledge all our Task 5.3 colleagues for their valuable ...


Current advances, research needs and gaps in mycotoxins biomonitoring under the...

Alvito, Paula; Assunção, Ricardo Manuel; Bajard, Lola; Martins, Carla; Mengelers, Marcel J.B.; Mol, Hans; Namorado, Sónia; van den Brand, Annick D.

Funding Information: Thanks are due to CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and ToxOmics (UIDB/00009/2020; UIDP/00009/2020), through national funds. L.B. thanks Research Infrastructure RECETOX RI (No. LM2018121), financed by the Ministry of Education, Youth and Sports, and the project CETOCOEN EXCELLENCE (No. CZ.02.1.01/0.0/0.0/17_043/0009632) for a supportive background of the European Union...


Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nano...

Rolo, Dora; Assunção, Ricardo; Ventura, Célia; Alvito, Paula; Gonçalves, Lídia; Martins, Carla; Bettencourt, Ana; Jordan, Peter; Vital, Nádia

Funding Information: This research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics (UIDP/00009/2020; UIDB/00009/2020), iMed.ULisboa (UIDB/04138/2020+UIDP/04138/2020), CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and BioISI (UID/MUL...


earlyMYCO

Martins, Carla; Assunção, Ricardo; Costa, Ana; Serrano, Débora; Visintin, Lia; De Boevre, Marthe; Lachat, Carl; Vidal, Arnau; De Saeger, Sarah

Funding Information: Funding: The earlyMYCO study was funded by Foundation for Science and Technology (PTDC/DTP-MEDTOX/28762/2017), by CESAM (UIDP/50017/2020+UIDB/50017/2020) and by the project MYTOX-SOUTH, Ghent University Global Minds programme. The funding sources were not involved in study design, in the collection, analysis and interpretation of data, and in the decision to submit the article for publicati...


Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Childre...

Alvito, Paula; Pereira-da-Silva, Luís

Funding Information: Funding: The APC was supported by the National Institute of Health Dr. Ricardo Jorge. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.; The first 1000 days of life are very sensitive to any event that alters health programming, and they represent a window for intervention to improve population health. Pregnant women, fetuses, and infants are particularly vulner...


Risk-benefit assessment of cereal-based foods consumed by portuguese children a...

Assunção, Ricardo; Boué, Géraldine; Alvito, Paula; Brazão, Roberto; Carmona, Paulo; Carvalho, Catarina; Correia, Daniela; Fernandes, Paulo; Lopes, Carla

Funding Information: This research was funded by European Food Safety Authority (EFSA) (Grant Agreement Number?GA/EFSA/AFSCO/2017/01?GA02) (The authors declare that this manuscript reflects only the authors? view and EFSA is not responsible for any use that may be made of the information it contains.). R.A., P.A. and C.M. also thanks FCT/MCTES for the financial support to CESAM (UIDP/50017/2020 + UIDB/50017/202...


Food consumption data as a tool to estimate exposure to mycoestrogens

Martins, Carla; Torres, Duarte; Lopes, Carla; Correia, Daniela; Goios, Ana; Assunção, Ricardo; Alvito, Paula; Vidal, Arnau; de Boevre, Marthe

Zearalenone and alternariol are mycotoxins produced by Fusarium and Alternaria species, respectively, that present estrogenic activity and consequently are classified as endocrine disruptors. To estimate the exposure of the Portuguese population to these two mycotoxins at a national level, a modelling approach, based on data from 94 Portuguese volunteers, was developed considering as inputs: i) the food consump...


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