4 documents found, page 1 of 1
The astrocyte α1A-adrenoreceptor is a key component of the neuromodulatory syst...
Wahis, J; Akkaya, C; Kirunda, AM; Mak, A; Zeise, K; Verhaert, J; Gasparyan, H; Hovhannisyan, S; Holt, MGNoradrenaline (norepinephrine) is known to modulate many physiological functions and behaviors. In this study, we tested to what extent astrocytes, a type of glial cell, participate in noradrenergic signaling in mouse primary visual cortex (V1). Astrocytes are essential partners of neurons in the central nervous system. They are central to brain homeostasis, but also dynamically regulate neuronal activity, nota...
Astrocyte structural heterogeneity in the mouse hippocampus
Viana, JF; Machado, JL; Abreu, DS; Veiga, A; Barsanti, S; Tavares, G; Martins, M; Sardinha, VM; Guerra-Gomes, S; Domingos, C; Pauletti, A; Wahis, JAstrocytes are integral components of brain circuits, where they sense, process, and respond to surrounding activity, maintaining homeostasis and regulating synaptic transmission, the sum of which results in behavior modulation. These interactions are possible due to their complex morphology, composed of a tree-like structure of processes to cover defined territories ramifying in a mesh-like system of fine leaf...
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-...
Yshii, L; Pasciuto, E; Bielefeld, P; Mascali, L; Lemaitre, P; Marino, M; Dooley, J; Kouser, L; Verschoren, S; Lagou, V; Kemps, H; Gervois, P; Boer, AThe ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification of both effective targets for local immune modulation and a delivery system capable of crossing the blood-brain barrier. The recent identification and characterization of a small population of regulatory T (Treg) cells...
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer...
Marino, M; Zhou, L; Rincon, MY; Callaerts-Vegh, Z; Verhaert, J; Wahis, J; Creemers, E; Yshii, L; Wierda, K; Saito, T; Marneffe, C; Voytyuk, ISingle domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous system (CNS), largely because of their restricted blood-brain barrier (BBB) penetration. Here, we propose a gene transfer strategy based on BBB-crossing adeno-associated virus (...