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Predation stress causes excessive aggression in female mice with partial geneti...
Svirin, Evgeniy; Veniaminova, Ekaterina; Nunes, João; Gorlova, Anna; Umriukhin, Aleksei; Kalueff, Allan V.; Proshin, Andrey; Anthony, Daniel C.The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of neuronal 5-HT synthesis and excessive aggressiveness in both male and female null mutant (Tph2-/-) mice. In heterozygous male mice (Tph2+/-), there is a moderate red...
Date: 2022
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Origin: Repositório da Universidade de Lisboa