15 documents found, page 1 of 2
The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antag...
Agache, I; Adcock, IM; Akdis, CA; Akdis, M; Bentabol-Ramos, G; van den Berge, M; Boccabella, C; Canonica, WG; Caruso, C; Couto, M; Davila, IAs cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long-acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in asthma patients who remained poorly controlled despite treatment with ...
Concepts for the development of person-centred, digitally-enabled, Artificial I...
Bousquet, J; Schünemann, HJ; Sousa-Pinto, B; Zuberbier, T; Togias, A; Samolinski, B; Bedbrook, A; Czarlewski, W; Hofmann-Apitius, M; Litynska, JThe traditional healthcare model is focused on diseases (medicine and natural science) and does not acknowledge patients' resources and abilities to be experts in their own life based on their lived experiences. Improving healthcare safety, quality and coordination, as well as quality of life, are important aims in the care of patients with chronic conditions. Person-centred care needs to ensure that people's v...
Consistent Trajectories of Rhinitis Control and Treatment in 16,177 Weeks: The ...
Sousa‐Pinto, B; Schünemann, HJ; Sá‐Sousa, A; Vieira, RJ; Amaral, R; Anto, JM; Klimek, L; Czarlewski, W; Mullol, J; Pfaar, O; Bedbrook, A; Brussino, LIntroduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for w...
Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A M...
Sousa-Pinto, B; Louis, R; Anto, J M; Amaral, R; Sá-Sousa, A; Czarlewski, W; Brussino, L; Canonica, G W; Chaves Loureiro, C; Cruz, A A; Gemicioglu, BIntroduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods: We analysed ...
Rhinitis Associated with Asthma is Distinct from Rhinitis Alone: The ARIA‐MeDAL...
Bousquet, J; Melén, E; Haahtela, T; Koppelman, GH; Togias, A; Valenta, R; Akdis, CA; Czarlewski, W; Rothenberg, M; Valiulis, A; Wickman, M; Akdis, MAsthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Comparison of Rhinitis Treatments Using MASK-air ® Data and Considering the Min...
Sousa‐Pinto, B; Schünemann, HJ; Sá‐Sousa, A; Vieira, RJ; Amaral, R; Anto, JM; Klimek, L; Czarlewski, W; Mullol, J; Pfaar, O; Bedbrook, A; Brussino, LBackground: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., "real-world data"). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal im...
Allergen immunotherapy for asthma prevention: A systematic review and meta-anal...
Farraia, M; Paciência, I; Castro Mendes, F; Cavaleiro Rufo, J; Shamji, M; Agache, I; Moreira, ABackground: Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated diseases. Randomized controlled trials (RCTs) support AIT's potential role in asthma prevention but evidence from non-randomized studies of interventions (NRSI) and longitudinal observational studies has been poorly addressed. Therefore, we aimed to conduct a systematic review and meta-analysis to assess clinical data fro...
Cost-effectiveness analysis of house dust mite allergen immunotherapy in childr...
Farraia, M; Paciência, I; Castro Mendes, F; Cavaleiro Rufo, J; Shamji, MH; Agache, I; Moreira, ABackground: Cost-effectiveness studies evaluating allergen immunotherapy (AIT) in children are limited but needed to drive clinical and policy-making decisions such as reimbursement of new interventions. In this study, we compared the cost effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) tablets to the standard of care (SOC) treatment in children with house dust mite-driven (HDM) allergi...
ARIA-EAACI Care Pathways for Allergen Immunotherapy in Respiratory Allergy
Bousquet, J; Pfaar, O; Agache, I; Bedbrook, A; Akdis, CA; Canonica, GW; Chivato, T; Al-Ahmad, M; Abdul Latiff, AH; Ansotegui, IJ; Bachert, C
ARIA Digital Anamorphosis: Digital Transformation of Health and Care in Airway ...
Bousquet, J; Anto, JM; Bachert, C; Haahtela, T; Zuberbier, T; Czarlewski, W; Bedbrook, A; Bosnic-Anticevich, S; Walter Canonica, G; Cardona, V; Costa, EDigital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validate...