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Dual-driven nanomotors enable tumour penetration and hypoxia alleviation for ca...

Wu, Jiaxue; Yi, Shixiong; Cao, Yingui; Zu, Menghang; Li, Baoyi; Yang, Wenjing; Shahbazi, Mohammad-Ali; Wan, Ying; Reis, R. L.; Kundu, Subhas C

The treatment efficacies of conventional medications against colorectal cancer (CRC) are restricted by a low penetrative, hypoxic, and immunosuppressive tumor microenvironment. To address these restrictions, we developed an innovative antitumor platform that employs calcium overload-phototherapy using mitochondrial N770-conjugated mesoporous silica nanoparticles loaded with CaO2 (CaO2–N770@MSNs). A loading leve...

Date: 2023   |   Origin: RepositóriUM - Universidade do Minho
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