3 documents found, page 1 of 1
Cocos nucifera oil decreases edema and mechanical hypernociception induced by B...
Lisboa-Neto, Álvaro S.; Ribeiro, Anita E. A. S.; Feitosa, Eliane F.; Wanderley, Carlos W. S.; Oliveira, Ana Paula deBothropic venoms cause intense local damage, pain, edema, and my - onecrosis. Cocos nucifera is the naturally most widespread fruit plant on Earth, and both the fruit and the plant have been used in folk medi - cine for the treatment of several inflammatory disorders. We evaluated the anti-inflammatory and analgesic effects of virgin coconut oil that was obtained from C. nucifera on paw lesions that were induce...
Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct...
Gomes, Bruno S.; S. Neto, Benedito P.; Lopes, Everton M.; Cunha, Francisco V. M.; Araújo, Alyne R.; Wanderley, Carlos W. S.; Wong, Deysi V. T.Myrtenol is a bicyclic monoterpene with anti-in fl ammatory properties. However, the mechanisms involved are partially unknown. Here, we investigated the effect of myrtenol during experimental chronic arthritis and the possible modulating activity of oxidative stress and neutrophil migration. Complete Freund's Adjuvant (CFA)-sensitized rats were treated with vehicle (1 mL/kg, po), myrtenol (12.5, 25 or 50 mg/kg...
The adaptor protein myd88 is a key signaling molecule in the pathogenesis of ir...
Wong, Deysi V. T.; Lima-Júnior, Roberto C. P.; Carvalho, Cibele B. M.; Borges, Vanessa F.; Wanderley, Carlos W. S.; Bem, Amanda X. C.Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves the Myeloid Differentiation adaptor protein, MyD88, whose role in intestinal mucositis is unknown. Then, we evalu...