5 documents found, page 1 of 1
Paclitaxel reduz o crescimento tumoral através da reprogramação de macrófagos a...
Wanderley, Carlos Wagner de SouzaPaclitaxel (PCX) is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action of this drug is based on microtubule stabilization and induction of mitotic arrest leading to cells that proliferate rapidly to apoptosis. Here, was investigated whether PCX could reprogram the antitumor immune response by modulating the functional phenotype of tumor-associated macrophages...
Bases da resposta inflamatória do trato gastrintestinal
Ribeiro, Ronaldo de Albuquerque; Lima Júnior, Roberto César Pereira; Souza, Marcellus Henrique Loiola Ponte de; Leite, Caio Abner Vitorino GonçalvesA inflamação é uma resposta vascular, celular e humoral, responsável pelo processo de defesa dos organismos vivos ante agentes agressores. Essa resposta fisiológica é resultante da ação coordenada entre o sistema imunológico e o tecido no qual ocorreu a lesão. Por incorporar vários mecanismos biológicos, como a formação de edema, fagocitose, angiogênese, fibroplasia, liberação de mediadores químicos, além de ou...
Role of the route of leukotrienes in an experimental model of oral mucositis in...
Silva, Viviane Carvalho da; Leitão, Renata Ferreira de Carvalho; Brito, Gerly Anne de Castro; Martins, Conceição da Silva; Freire, Gildenio EstevamPurpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administ...
Veneno da serpente Bothrops jararacussu induz uma resposta inflamatória local d...
Wanderley, Carlos Wagner de SouzaLocal tissue reactions provoked by Bothrops venoms are characterized by edema, hemorrhage, pain, and inflammation; however, the mechanisms of tissue damage vary depending upon the species of snake. This mechanistic variability reduces the efficacy of antivenom treatment. Considering the diversity of intraspecific pathophysiological responses, we investigated the mechanisms and mediators involved in the local in...
Biometry of head and cranial cavity of wooless mongrel sheep (Ovis aries LINNAE...
Costa, Fernando Santos; Rodrigues, Rafael Torres de Souza; Wanderley, Carlos Wagner de Souza; Pereira Neto, Joaquim; Faria, Marcelo Domingues deThe sheep is a commonly used species in Northeast region of Brazil because of its high rusticity. Yet, very little is known about the anatomy of these species. Therefore, the number of studies in this field is increasing to stimulate technical and scientific subsidies to professionals in Veterinary Medicine. The aim of this study was to establish correlations between the head and cranial cavity dimensions, usin...