5 documents found, page 1 of 1
Effect of progesterone on Candida albicans biofilm formation under acidic condi...
Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Schroeder, Markus; Pedro, Nuno A.; Butler, Geraldine; Azeredo, Joana; Henriques, MarianaVulvovaginal candidiasis (VVC) caused by Candida albicans is a common disease worldwide. A very important C. albicans virulence factor is its ability to form biofilms on epithelium and/or on intrauterine devices promoting VVC. It has been shown that VVC has a hormonal dependency and that progesterone affects virulence traits of C. albicans cells. To understand how the acidic environment (pH 4) and progesterone ...
The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Pereira, L. P.; Silva, Sónia Carina; Salazar, Sara B.; Schröder, Markus S.; Okamoto, MichiyoTo thrive in the acidic vaginal tract C. glabrata has to cope with high concentrations of acetic acid. The mechanisms underlying C. glabrata tolerance to acetic acid at low pH remain largely uncharacterized. In this work it is demonstrated the essential role of the CgHaa1 transcription factor (encoded by ORF CAGL0L09339g) in the response and tolerance of C. glabrata to acetic acid. Transcriptomic analysis showe...
Progesterone modulates Candida albicans biofilm formation / expression
Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Butler, Geraldine; Azeredo, Joana; Henriques, Mariana; Mira, Nuno; Silva, Sónia CarinaVulvovaginal candidiasis (VVC) caused by Candida albicans is a common disease worldwide. The most important C. albicans virulence factor is its ability to form biofilms, which, in the vaginal environment, may be formed on the epithelium and on intrauterine devices. Despite it has been shown that VVC has a hormonal dependency, the effects of progesterone on biofilm formation by C. albicans are still poorly under...
Genetic adaptive mechanisms mediating response and tolerance to acetic acid str...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Chibana, Hiroji; Silva, Sónia Carina; Sá-Correia, Isabel; Azeredo, Joana; Butler, GeraldineC. glabrata is a commensal found in the human genitourinary tract but under certain conditions this harmless colonization evolves to a mucosal infection and, in more serious cases, to disseminated mycosis. To thrive in the acidic vaginal tract C. glabrata has to cope with the presence of a competing commensal microbiota known to restrain the overgrowth of pathogens through the production of acetic and lactic ac...
The CgHaa1-dependent pathway mediates Candida glabrata response and tolerance t...
Bernardo, Ruben; Silva, Sónia Carina; Cunha, Diana V.; Pereira, Leonel; Wang, Can; Correia, Isabel Sá; Chibana, Hiroji; Butler, GeraldineTo successfully colonize the vaginal tract Candida glabrata has to cope with various stresses including the presence of acetic acid at a low pH that is produced by the bacteria that co-colonize this niche. The genes/pathways involved in C. glabrata tolerance and response to acetic acid are largely unknown, although these are a highly interesting set of novel targets to control vaginal infections caused by this ...