2 documents found, page 1 of 1
Multifunctional dendrimer-entrapped gold nanoparticles conjugated with Doxorubi...
Zhu, Jingyi; Wang, Guoying; Alves, Carla S.; Tomás, Helena; Xiong, Zhijuan; Shen, Mingwu; Rodrigues, João; Shi, XiangyangNovel theranostic nanocarriers exhibit a desirable potential to treat diseases based on their ability to achieve targeted therapy while allowing for real-time imaging of the disease site. Development of such theranostic platforms is still quite challenging. Herein, we present the construction of multifunctional dendrimer-based theranostic nanosystem to achieve cancer cell chemotherapy and computed tomography (C...
Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robus...
Wang, Guoying; Maciel, Dina; Wu, Yilun; Rodrigues, João; Shi, Xiangyang; Yuan, Yuan; Liu, Changsheng; Tomás, Helena; Li, YulinThe development of pH-sensitive drug delivery nanosystems that present a low drug release at the physiological pH and are able to increase the extent of the release at a lower pH value (like those existent in the interstitial space of solid tumors (pH 6.5) and in the intracellular endolysosomal compartments (pH 5.0)) is very important for an efficient and safe cancer therapy. Laponite (LP) is a synthetic silica...