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Mefloquine–Oxazolidine derivatives : a new class of anticancer agents
Rodrigues, Felipe A. R.; Bomfim, Igor da S.; Cavalcanti, Bruno C.; Pessoa, Claudia; Goncalves, Raoni S. B.; Wardell, James L.; Wardel, Solange M. S. V.A series of 23 racemic mefloquine–oxazolidine derivatives, 4-[3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin- 1-yl]-2,8-bis(trifluoromethyl)quinolines, derived from (R*, S*)-(±)-mefloquine and arenealdehydes, have been evaluated for their activity against four cancer cell lines (HCT-8, OVCAR-8, HL-60, and SF-295). Good cytotoxicities have been determined with IC50 values ranging from 0.59 to 4.79 lg/mL. In general...
Data: 2014
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Origem: Oasisbr